The OHSU Knight Cancer Institute, known as one of the pioneers in personalized cancer medicine, is an international leader in research and cancer treatment. Driven by its mission to end cancer as we know it, the institute is building upon its expertise in targeted treatments to advance the early detection of cancer when the disease is most treatable.
With decades of academic laboratory experience in diagnostic molecular pathology, the Knight Diagnostic Laboratories deliver advanced diagnostic testing to make personalized medicine a reality.
Specializing in designing, validating, and delivering cutting edge assays for oncology, the laboratories are CLIA certified and CAP accredited. Our large ever-expanding menu of molecular diagnostic assays, with a particular focus on next-generation sequencing, directly informs the clinical care of oncology patients, contributes to translational and clinical research projects with academic and private sector collaborators, and is the basis for our ACGME-accredited molecular genetic pathology educational program.
We seek an experienced laboratory scientist to lead the complex process of new clinical/translational assay development from project inception and scoping through clinical validation and troubleshooting, including: assessment/prioritization of clinical utility, assay design (using local and national informatics resources), sample selection, data manipulation/analysis/cleaning, laboratory validation, protocol creation, technology transfer to technical staff, quality improvement, and troubleshooting. This individual must be able to work independently and with our team of lab scientists, bioinformaticists, and molecular pathologists to create, manipulate and analyze large complex data sets and interpret their clinical relevance. The ideal candidate will be expected to both work hands-on at the wet lab bench performing new and traditional lab assays (with an emphasis on next-generation sequencing) and also at the computer developing, creating, analyzing, and manipulating the analysis “pipeline” for the new assays. Formal programming/informatics training will be helpful, but not necessary, as an on-site team of informatics specialists will be available for training/consultation. The routine interpretive assistance tools will be bioinformatics programming (public, self-designed, and proprietary), comprehensive medical literature searches, online genomic databases (COSMIC, etc), KDL’s in-house genomic database, and a variety of NGS variant interpretive software tools. The routine work products will be 1) cleaned, coded data sets of patient-derived samples assessed by new genomic assays and annotated with other clinical and laboratory data; 2) validation summaries and standard operating procedures (including research papers and grants) for new clinical assay development projects; and 3) detailed descriptions / programs for new assay analysis methods.
Opportunities for participation in research projects/grants/papers will be plentiful. This individual will be located within OHSU Knight Diagnostic Laboratories and will report to the Laboratory Directors. For the laboratory scientist with experience in with both hands-on wet lab experimentation and computer–based data manipulation /analysis, assay design/validation (NGS-based), this position will be a great opportunity to become a key contributor to our unique environment at the intersection of patient care and translational research.
1. Every Knight Cancer employee is expected to embody our guiding principles:
2. Develop new assays (NGS and non-NGS) for eventual clinical/translational use in KDL (concept design, sample selection, lab validation, data analysis/manipulation/interpretation/cleaning)
3. Develop and validate data analysis methods for new assays
4. Be part of the leadership team that develops/validates/troubleshoots new KDL assays
5. Plan, execute, analyze, and write up results for research projects
6. Mentor/train/teach/troubleshoot with other lab members (fellows, residents, technologists, faculty)
Education and Experience:
Job Related Knowledge:
Education & Experience:
Please submit a resume and cover letter for your application to be considered.
Please note: As of Oct. 18, 2021, all OHSU employees are required to be fully vaccinated against COVID-19. Fully vaccinated means you have received both doses of a two-dose, or one dose of a single-dose, FDA- or WHO-authorized COVID-19 vaccine and at least 14 days have passed since your final dose of COVID-19 vaccine. If you apply for and are offered a position, you must be fully vaccinated prior to starting work.
If the position you are offered does not require direct, in-person patient care contact, you may request an exception to the vaccine policy for medical or religious reasons. OHSU uses very narrow criteria under the law to allow an exception and very few requests are being approved.