The laboratory of Dr. Megan Burger in the Department of Cell, Developmental and Cancer Biology at Oregon Health and Science University seeks a highly motivated Postdoctoral Scholar to work in the exciting field of cancer immunotherapy. Dr. Burger’s research program is focused on uncovering therapeutic strategies to promote T cell immunity against tumors using genetically engineered mouse models of lung cancer. Prior work has uncovered a role for immunodominance (i.e. competition between T cells responding to different antigens) in limiting the breadth and functionality of anti-tumor T cell responses. The focus of this position will be on investigating factors contributing to establishment of immunodominance and identifying therapeutic approaches to better synergize T cell responses against cancer. Mechanistic studies in mice will be complemented with studies of human samples to facilitate translation of findings to the clinic.
The Postdoctoral Scholar will work collaboratively with Dr. Burger to develop research directions and will independently drive project aims. The ideal candidate will have experience working with mouse disease models and extensive expertise in cellular and molecular biology techniques and immunological assays, including flow cytometry, adoptive cell transfers, bone marrow chimeras, etc. We seek a creative and pioneering individual interested in applying a multidisciplinary approach to their work, incorporating cutting-edge mouse genetics, transcriptomics and spatial profiling technologies. The candidate should also be a team-player with interest in collaborative work and mentorship of junior personnel.
The candidate should have no more than 1 year of postdoctoral experience, and will be expected to compete for internal and external funding. Applicants should upload a cover letter describing your relevant qualifications, future interests, and expected start date; CV; and names and contact information for three references.
Ph.D. or M.D./Ph.D., in related field of study
First authorship on at least one paper in a peer-reviewed English language journal is required.
Excellent written and verbal communication skills.
Experience with mouse models of disease, cell culture, molecular biology techniques (qPCR, cloning, western blotting, etc.), and immunological assays (flow cytometry, ELISA, adoptive cell transfer, etc.).
Work is generally 40 hours per week during regular business hours, however, evening and weekend work will be necessary on occasion. Additional safety training will be required to work with cell lines/ infectious bacteria or viruses/ working with in a BSL-2 environment. Use of dosimeter and adherence to radiological safety ordinances is required. Working with laboratory animals is required.
Personnel will need to work at lab benches, desks and/or microscopes for up to 4 hours at a time. Ability to perform repetitive lab manipulations (gripping, grasping, reaching, twisting), move lab equipment under 25 lbs with accommodation, perform image analysis operation and help others with equipment use. Personal protective equipment must be worn as required. (Gloves, mask/respirator, eyewear, lab coat, dosimeter, etc).