The mission of the department of Cell, Developmental and Cancer Biology at OHSU is to improve our basic understanding of biological mechanisms relevant to human health and disease. The department is composed of 25 faculty with research spanning mechanisms of cellular crosstalk, epigenetic regulation, cell signaling, and immune activation across cancer, infection, and other disease pathologies.
A postdoc position in cancer immunology is available in the lab of Dr. Megan Burger at the OHSU Knight Cancer Institute. We seek an enthusiastic and dedicated Ph.D. scientist with experience in immunology and/or cancer biology and mouse models to join our team.
The Burger Lab is focused on uncovering factors regulating T cell responses against cancer to inform the design of next generation cancer immunotherapies. We utilize genetically engineered mouse models of lung cancer paired with novel genetic tools and single-cell analysis platforms, including high dimensionality flow cytometry, single-cell RNA-sequencing, and spatial profiling to deeply investigate tumor-immune crosstalk. Mechanistic studies and preclinical immunotherapy trials in mice are complemented with analysis of human samples to facilitate potential translation of our findings to the clinic.
We are looking for a postdoc to lead projects in one of three areas: 1) antigen-driven dynamics of the T cell response and cancer vaccine strategies, 2) tumor-intrinsic mechanisms of T cell evasion, or 3) lymphocyte networks and spatial regulation of T cell responses to immunotherapy. More information on our research and relevant publications can be found at our website: https://www.ohsu.edu/school-of-medicine/burger-lab.
The postdoc will work collaboratively with Dr. Burger to develop research directions and will independently drive project aims. The ideal candidate will have experience working with mouse disease models, extensive expertise in basic cellular and molecular biology techniques, and some experience with immunological assays, including flow cytometry, adoptive cell transfers, ELISA, etc. We seek a creative and pioneering individual interested in applying a multidisciplinary approach to their work, incorporating cutting-edge mouse genetics, transcriptomics and spatial profiling technologies. The candidate should also be a team-player with interest in collaborative work within the lab and across the institution and mentorship of junior personnel.
In addition to scientific training, the postdoc will receive personalized mentorship in developing career goals. Guidance will be given in posing research questions, project management, scientific writing, public speaking, network building, leadership, and mentoring. The postdoc will have opportunities to present their research at internal research-in-progress seminars and will be able to attend at least one national scientific conference per year.
The candidate should have no more than 1 year of prior postdoctoral experience, and will be expected to compete for internal and external fellowship funding. Applicants should upload a cover letter describing your relevant qualifications, future research and career interests, and expected start date; CV; and names and contact information for three references.
Work is generally 40 hours per week during regular business hours; however, evening and weekend work will be necessary on occasion. Additional safety training will be required to work with cell lines/ infectious bacteria or viruses/ working within a BSL-2 environment. Use of dosimeter and adherence to radiological safety ordinances is required. Working with laboratory animals is required.
Personnel will need to work at lab benches, desks and/or microscopes for up to 4 hours at a time. Ability to perform repetitive lab manipulations (gripping, grasping, reaching, twisting), move lab equipment under 25 lbs with accommodation, perform image analysis operation and help others with equipment use. Personal protective equipment must be worn as required (gloves, mask/respirator, eyewear, lab coat, dosimeter, etc.).
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