The research laboratory of Professor Andrew Emili pursues collaborative multi-disciplinary systems biology projects within the OHSU Knight Cancer Institute. The Knight Cancer Institute, known as one of the pioneers in personalized cancer medicine, is an international leader in research and cancer treatment. This is an ambitious group, one that requires novelty, creativity, and innovation. We are composed of experimental biologists, protein biochemists, analytical chemists, biomedical engineers, and computationalists conducting groundbreaking research to understand disease mechanisms and identify novel drug targets, to ultimately help people maintain a high quality of life and reduce cancer mortality, while creating a broader systems biology research community.

Every Knight Cancer member is expected to embody our guiding principles:

• We act BOLDLY—Breakthroughs require pushing the boundaries of science, exploring new frontiers, and thinking differently
• We SUPPORT each other—Respect leads to trust, which leads to excellence
• We work as a CONNECTED team — We must leverage our collective brain power to conquer cancer because no one individual can do it alone

The Emili laboratory is currently seeking applicants to fill multiple postdoctoral positions. The lab offers a unique opportunity for outstanding, driven, and creative postdoctoral fellows to perform cutting edge proteomics research, ranging from understanding basic cancer biology to developing novel technologies to aid disease detection and drug development. The Emili laboratory is dedicated to promoting inclusion and multiculturalism to build a successful team by having outstanding researchers of diverse backgrounds work together on multiple projects. We encourage high-risk, high-reward research projects because defeating cancer requires innovation and out-of-the-box thinking.

As a Post-Doctoral Fellow, you will support mass spectrometry-focused proteomics studies within the Emili network systems biology laboratory, a new leading faculty member of the Knight Cancer Institute at Oregon Health and Science University. Major projects involve interrogation of animal model and primary patient specimens, primarily but not limited to biopsies, tissue specimens and cultured cells, to identify and validate biological systems, protein complexes and biochemical pathways altered in across multiple cancer indications and to support examination of biological mechanisms of action. The major role for the candidate will be to serve as an experimentalist and a proteomic mass spectrometry data generator.  This role will involve executing a number of research projects throughout their lifespan including providing significant input on experimental study design, control inclusion and placement, data acquisition strategies and, critically, analysis and mining of the resulting datasets.  Additional and important roles for the candidate will involve performing sample acquisition and processing, instrument optimization, data acquisition, and organized tracking of samples, datasets, and relevant methods (both experimental and analytic) for summary scientific reports, presentations and eventual publications.  The candidate will be required to explore and apply advanced LC/MS-based proteomic capabilities, including affinity-labeling/capture, quantitative and integrative-analyses, and will need to scale analytic platforms and algorithms for larger-scale studies.  The candidate should operate effectively with internal team members and actively solicit input from expert external analytic consultants and collaborators.  The candidate will likely be required to oversee more junior analysts and experimental researchers and train them on methods and approaches to build redundancy of expertise as much as possible.  The candidate will demonstrate the ability to independently design, execute and interpret proteomic method development studies critical to the evolution of our workflows to support early detection and other clinical sample interrogation.

• PhD
• 3 years, proteomics/analytical chemistry or closely related discipline
• Exceptional self –starter
• Computational skill with latest versions of proteomic software such as MaxQuant, Spectronaut, and MSStats.  Experience with biochemical methods for processing and quality control analysis of proteins and peptides for analytic endpoints, especially mass spectrometry
• An understanding of, and ideally previous experience with, shotgun mode mass spectrometry analysis of protein/peptide mixtures
• Ability to prioritize multiple tasks at one time
• Excellent communication, analytical and organizational skills:  both written and verbal
• Ability to work independently and as part of a team while being collaborative in resolving problems
• Intermediate skills with Microsoft Office (Excel, Outlook, Access, Word, and PowerPoint)

• 5 years, proteomics/analytical chemistry or closely related discipline
• Experience in implementing targeted proteomic methods such as parallel reaction monitoring (PRM) on Orbitrap MS instruments
• Experience in using high/medium pressure liquid chromatography for sample preparation and for inline sample delivery to nanospray MS sources
• Skill in chemical labeling and crosslinking of protein and peptide samples for MS analysis

Apply online. Please be sure to upload a Cover Letter and Resume/CV.

Effective Oct. 18, 2021, all OHSU employees were required to be fully vaccinated against COVID-19 unless they had an approved medical or religious exception. If you are hired by OHSU, you will need to provide proof of vaccination (or approved exception) within 10 days of starting work. 

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Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.