Oregon Health & Science University

Associate Core Scientist

Job Locations US-OR-Portland
Requisition ID
2022-20179
Position Category
Research
Position Type
Regular Full-Time
Job Type
Research
Department
University Shared Resources
Salary Range
$57,969 - $86,832 Commensurate with qualifications, experience and internal equity
FTE
1.00
Schedule
Monday - Friday
Hours
8:00 am - 5:00 pm with occasional nights and weekends
HR Mission
Research
Drug Testable
No

Department Overview

We are seeking a talented, motivated and highly interactive individual to work in a multidisciplinary team at OHSU as part of the Multiscale Microscopy Core (MMC).  Included at this OHSU Electron Microscopy Core are two Transmission Electron Microscopes (TEM), a Tecnai T12 Biotwin, and a Glacios cryoTEM microscope (outfitted with a K3 direct electron detector). This facility also has a Helios G3 FIB-SEM, a newly installed Helios UC5 FIB-SEM equipped with Oxford EDS detector and Leica cryo stage, a Teneo SBF-SEM and a CorrSight for correlative light and EM projects.

 

The Associate Core Scientist will provide support to the MMC’s activities and core director by communication with core facility users, providing sample preparation, imaging acquisition and training to new users and junior staff. The candidate will also be involved in laboratory maintenance including consumables and reagents restocking, operations with advanced electron microscope equipment (TEM, cryoTEM, SEM, FIB-SEM and SBF-SEM) and provide assistance with organization of laboratory events including training and workshops.  The candidate will provide administrative support of laboratory operations including iLabs, ordering, maintenance of records and inventory databases and liaising with the manufacturers and vendors for purchases, repairs, upgrades and application support.  It is expected for this candidate maintain current knowledge with literature and database searches on topics relevant to the projects, methodology and instrumentations of the core.

 

The candidate will be expected to help maintain a smooth and efficient working environment by providing services to internal and external users and assisting with training and support.  This includes troubleshooting sample preparations and helping with long semi-automated data collection runs.  The candidate will have the opportunity to develop new workflows in the core. 

The Core Scientist family provides technology expertise for researchers across campus. Core Scientists are involved with providing service functions in a core that depending on the core include service projects, assay services, or equipment training. Core management duties includes responsibilities for service quality assurance and compliance, project and request tracking, financial duties around recharge mechanisms, and user outreach. Core leadership duties include operational and financial oversight, reporting, staff recruitment, training, and mentoring, and staff and user management. 

 

For consideration, upload cover letter and CV/resume, along with 3 professional references who can speak to your experiences and abilities.

Function/Duties of Position

 GENERAL LAB SUPPORT (70%):

  • Assist in supporting the daily function of the MMC maintaining all laboratory equipment, under the supervision of the MMC director.
  • Providing training to MMC users on lab practices and protocols, including sample preparation and instrumentation use.
  • Provide general Core Services including sample prep, imaging, and data distribution.  Assist and advice users in the development of EM protocols for sample preparation and imaging for their unique research needs.
  • Perform standard and advanced sample preparation for electron microscopy including bench processing, microwave methods, high pressure and plunge freezing, ultramicrotomy, automated processing, negative staining, immuno-gold labeling, cryo sectioning and correlative light and EM protocols.
  • Prioritize and identify daily work activities to achieve objectives of the MMC CORE.
  • Providing training to MCC junior lab members on lab practices and protocols, including sample preparation, instrumentation use and setting up automated data acquisition.
  • Maintain detailed records and standardized protocols for training, and of experimental procedures, data collection and analysis methods.
  • Maintain an accurate and detailed laboratory notebook of all projects supervised by the employee.

COMPLIANCE AND SAFETY FUNCTIONS (30%): 

  • Maintain laboratory compliance documentation for radiological work.  
  • Maintain the chemical log and all MMC documentation for compliance with EHS requirements.
  • Be familiar with lab safety infrastructure and ensure compliance with all safety regulations.
  • Interact with biosafety, chemical safety, and safety officers on behalf of the Principal Investigator. 

Required Qualifications

  • Master's Degree in relevant field AND 3 year experience or core-relevant expertise OR 
  • Bachelor's with relevant coursework AND 5 years of relevant experience or core-relevant expertise.
  • Skilled in operating Transmission EM (Room temperature and cryo) and Scanning EM.
  • Basic knowledge on FIB-SEM and SBF-SEM to acquire 3D datasets.
  • Skilled in ultramicrotomy and can train novice user.
  • Skilled in EM sample preparation techniques (room temperature and cryo).
  • Experience with training novice users on services provided in the core.
  • Ability to develop new workflows and protocols important to the core and users.
  • Maintains record of supplies, coordinates chemical waste disposal, manages iLabs for calendar reservations and billing as needed, provides users with cost estimates for projects.
  • Maintain a high level of professional expertise through familiarity with current scientific literature.
  • Ability to multi-task efficiently and demonstrate good time management skills.
  • Well organized, dependable and work as a team member to accomplish research goals. 
  • Excellent communication skills with strong ability to organize, document and analyze research data.
  • Demonstrated ability to work independently and as a team member to accomplish research goals.
  • Experience handling chemical and biologically hazardous materials.
  • Ability to follow lab safety regulations and lab compliance protocols.

Preferred Qualifications

  •  Experience working in a service center.
  • Image processing for SPA.
  • Demonstrated ability to set up automated data acquisition for single particle studies.
  • Tomography data collection and reconstruction.
  • Knowledge in Tokuyasu sectioning and high pressure freezing techniques.
  • Previous experince using cryo-EM, and direct electron detectors.
  • Experience managing expensive instrumentation. 

Additional Details

  • This position is located in the Robertson Life Science Building on OHSU’s South Waterfront campus; work hours are 8am – 5pm with occasional evening and weekend work as needed.
  • Exposure to chemicals and gases (liquid nitrogen) in use of preparation of samples.
  • Additional safety training will be required to work with cell lines/ infectious bacteria or viruses/ working with in a BSL-2 environment.
  • Ability to work at a computer for up to 6 hours at a time.
  • Ability to use and maintain microscopy and imaging equipment.
  • The worker is required to have close visual acuity to perform an activity such as: preparing and analyzing data and figures; viewing a computer terminal; extensive reading.
  • Ability to perform repetitive manual manipulations (gripping, grasping, fingering, pinching, etc.)
  • Ability to communicate complex ideas to customers and co-workers.
  • Personal protective equipment must be worn as required. (Gloves, mask/respirator, eyewear, lab coat, etc).

All are welcome

Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.


As an organization devoted to the health and well-being of people in Oregon and beyond, OHSU requires its employees to be fully vaccinated against COVID-19.

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