The Nan lab is looking for a motivated postdoc scholar to work on multiplexed super resolution microscopy and its applications to cancer biology. The projects will involve cutting-edge optical microscopy, biological sample handling, as well as in depth image analysis.

Our lab has pioneered the development of quantitative SRM, such as quantitative photoactivated localization microscopy (qPALM, Nan et al PNAS 2013), and used it to discover the role of Ras dimers in oncogenic signaling (Nan et al. PNAS 2015), a new direction in the Ras biology field with important basic and translational implications (Chen et al. Mini Rev Med Chem. 2016; Ozdemir et al. Genes 2022). More recently, we have extended DNA point accumulation in nanoscale topography (DNA-PAINT) into a fast, convenient tool for multiplexed SRM imaging (Huang et al Biophys. J. 2018; Civitci et al. Nature Comms, 2020). The tools have been used to study Ras biology (ongoing, NIH-supported project), pancreatic cancer (ongoing project, Rames et al. 2022) and other important cancer biology problems (e.g. Zheng et al. Science, 2021). Please consult our lab website (http://www.ohsu.edu/nan) for more details.

 

The ideal candidate is expected to have solid training and perferrably research experience in one or more of these fields: biochemistry and cell biology; biophysics; chemical / bio / biomedical engineering. Experience with recombinant protein expression, bioconjugations, and/or biological sample handling (such as immunofluorescence sample preparation) is a plus.

Successful candidates will have a unique opportunity to work closely with team members in diverse expertise areas including optics, imaging, computation, biochemistry, and cancer biology.

• Conduct original research
• Scientific and technical discussions, presentations, and publishing
• Contributing to grant proposals
• Collaborations, mentoring

• PhD in biological sciences or related field
• 3+ years of research experience (PhD included) in quantitative biological imaging and/or biophysics
• Strong expertise in cell biology, high-resolution microscopy sample preparation and image acquisition

• PhD in (bio)physics, bio(medical) engineering, or chemical engineering
• Expertise in quantitative image analysis, proficiency in a major scientific programming language

Typical wetlab (bench and tissue culture) environment; microscopy lab with custom optics and electronics. Ability to operate microscopes for a few hours (with short breaks) in a row.

Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.


As an organization devoted to the health and well-being of people in Oregon and beyond, OHSU requires its employees to be fully vaccinated against COVID-19.