OHSU Knight Cancer Institute, known as one of the pioneers in personalized cancer medicine, is an international leader in research and cancer treatment. Driven by its mission to end cancer as we know it, the institute is building upon its expertise in targeted treatments to advance the early detection of cancer when the disease is most treatable. 

With decades of academic laboratory experience in diagnostic molecular pathology, the Knight Diagnostic Laboratories (KDL) deliver advanced diagnostic testing to make personalized medicine a reality. Specializing in designing, validating, and delivering cutting edge assays for oncology, the laboratories are CLIA certified and CAP accredited.  IMCO (Immune Monitoring and Cancer Omics Laboratory) is an arm of KDL which focuses on RUO research assays and external industry and academic collaborations.

We seek an experienced scientist with background in immunology/cancer biology to lead our CyTOF and mIHC assays wet bench analytics as well as the complex process of new translational assay development from project inception and scoping through validation and troubleshooting. 

This position would report to the director of IMCO and work closely with IMCO’s project managers and bioinformatics team. 

The right candidate must be able to work independently and with our team of lab scientists and bioinformaticists, to lead our CyTOF and mIHC efforts including all necessary wet bench work and collaborate with our bioinformatics group to analyze and interpret data generated in terms of clinical relevance, statistical and biological significance.  The ideal candidate will be expected to both work hands-on at the bench performing new and traditional lab assays (with an emphasis on CyTOF and mIHC) and also at the computer developing, creating, analyzing, and manipulating the analysis “pipeline” for the new assays. The routine work products will be 1) Planning experiments using current assays and panels for CyTOF and mIHC assuring adherence to deliverables and time sensitive deadlines 2) Validation of new assays and optimizing existing workflows following standard operating procedures and 3) detailed record keeping of current projects 4) assuring GLP-like implementation of high rigor and assay reproducibility. 

Opportunities for participation in research projects/grants/papers will be plentiful. This individual will be located within OHSU Knight Diagnostic Laboratories and will report to IMCO Director. For the laboratory scientist with experience with both hands-on wet lab experimentation and new assay design/validation this position will be a great opportunity to become a key contributor to our unique environment at the intersection of patient care, translational research and industry clinical drug development. 

Duties will include:

• Every Knight Cancer employee is expected to embody our guiding principles:
  • We act BOLDLY—Breakthroughs require pushing the boundaries of science, exploring new frontiers, and thinking differently
  • We SUPPORT each other—Respect leads to trust, which leads to excellence
  • We work as a CONNECTED team — We must leverage our collective brain power to conquer cancer because no one individual can do it alone
• Develop new assays) for eventual clinical/translational use in IMCO (concept design, sample selection, lab validation, data analysis/manipulation/interpretation/cleaning)
• Implement and perform current CyTOF and mIHC assays as needed
• Be part of the leadership team that develops/validates/troubleshoots new IMCO assays
• Plan, execute, analyze, and write up results for research projects
• Mentor/train/teach/troubleshoot with other lab members (scientists, technologists, faculty and bioinformaticists)

Education & Experience:

• Doctoral degree with major courses in relevant field
• 3+ years of practical post-doctoral lab experience

Job Related Knowledge, Skills and Abilities (Competencies):

• Ability to prioritize multiple tasks at one time
• Must have excellent communication, analytical and organizational skills:  both written and verbal
• Ability to work independently and as part of a team while being collaborative in resolving problems
• Must be proficient with computers running Windows and PC applications (e.g. MS Excel, Word, PowerPoint) and other advances data analysis tools/software
• Must be able to learn (and create) new software tools/pipelines for analyzing/manipulating new assay data

Education & Experience:

• Ph.D. with both wet lab and data analysis/programming experience
• CyTOF or FLOW experience preferred, including strong analysis skills using FCS or Pathsetter and FlowJo
• Experience in a clinical/translational/diagnostic lab environment

Job Related Knowledge, Skills and Abilities (Competencies):

• In depth understanding of cancer biology and immunology, CyTOF and immunohistochemistry assays, PUBMED literature review, data analysis and interpretation, statistics
• Familiarity with working with human samples
• Computer programming an added benefit

Please submit a resume and cover letter for your application to be considered. 

Please note: As of Oct. 18, 2021, all OHSU employees are required to be fully vaccinated against COVID-19. Fully vaccinated means you have received both doses of a two-dose, or one dose of a single-dose, FDA- or WHO-authorized COVID-19 vaccine and at least 14 days have passed since your final dose of COVID-19 vaccine. If you apply for and are offered a position, you must be fully vaccinated prior to starting work. 

If the position you are offered does not require direct, in-person patient care contact, you may request an exception to the vaccine policy for medical or religious reasons. OHSU uses very narrow criteria under the law to allow an exception and very few requests are being approved.

 

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As an organization devoted to the health and well-being of people in Oregon and beyond, OHSU requires its employees to be fully vaccinated against COVID-19.