Oregon Health & Science University

Senior Research Assistant

Job Locations US-OR-Portland
Requisition ID
2023-22125
Position Category
Research
Position Type
Regular Full-Time
Job Type
Research
Department
Dermatology
Salary Range
$43,536.48 - $59,909.46 Commensurate with qualifications, experience and internal equity
FTE
1.00
HR Mission
School of Medicine
Drug Testable
No

Department Overview

The OHSU Dermatology Research Division merges basic, clinical and translational research in epithelial cell cancers and dermatologic diseases. Our basic and clinician-scientists are committed to innovative research on cancer and inflammation of skin with an impact on understanding causes and improving future treatment of muco-cutaneous diseases and providing more effective patient care.

 

The person who fills this position will work with Rajan Kulkarni, M.D., Ph.D., to investigate methods for early detection of melanoma and other cancers and their recurrence with the goal of enabling translational studies. Research projects include studies of methods for identifying melanoma signatures in the blood and collaboration with other groups performing similar projects. The ability to independently design and implement experiments, to take primary responsibility for a mouse colony, and to contribute to the management of laboratory operations will be expected of this person.

 

The Senior Research Assistant will design and implement projects, carrying out advanced protocols, including cell culture, basic molecular biology (DNA, RNA and protein extraction from blood, tissue and saliva, sequencing, design and validation of sequencing and qPCR primers, simple cloning), protein analysis by Western blot, and flow cytometry; will analyze sequencing data; and will contribute to manuscripts, grant applications, and protocols. The Senior Research Assistant will manage the Kulkarni Lab’s mouse colony and design syngeneic mouse models of cutaneous melanoma experiments.

Function/Duties of Position

  • Designs and monitors mouse colony and mouse model experiments; checks and maintains welfare of animals, keeps detailed up-to-date records, collects tissues, and performs surgical procedures.
  • Designs and carries out cell culture experiments with cell lines and primary human skin cells. Analyzes results using techniques listed in position summary.
  • Helps to isolate DNA, RNA and cells from blood and biological fluid samples.
  • Performs sequence analysis on blood and tissue-derived DNA from clinical study participants and assists with other data analysis.

Required Qualifications

  • Bachelor’s Degree (4 yr) with major courses in biology and chemistry
  • 1–3 years of experience in a biomedical research lab, including experimental mouse/rodent handling experience

  • Competent math skills, experience with MS Excel

Preferred Qualifications

  • Master’s degree in relevant field
  • Knowledge of next generation sequencing data analysis

Additional Details

  • The schedule will be full-time (40 hours per week), though the hours can be flexible on mutual agreement and will include evening and weekend work as needed for mouse colony maintenance. The location will be primarily in the dermatology laboratory and associated equipment rooms in the Center for Health and Healing. Specialized experiments will be conducted in core facilities. Exposure as part of this position may include human tissues and fluids. Small animal work (mice) could include monitoring mice, euthanasia, ex vivo tissue collections and processing, depending on the experiments performed.
  • Ability to stand to work at laboratory bench and sit for hours when needed for pipetting, tissue culture or microscopy.

All are welcome

Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.

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