The Mansoor lab seeks a postdoctoral scholar who is interested in structural biology and drug development. The scholar will receive training in the expression and purification of membrane proteins for biophysical and structural analysis, specifically single particle cryogenic electron microscopy (Cryo-EM), as well as training in electrophysiology.

 

Applicants must be NIH training grant eligible (US Citizen or Green Card holder).

 

Applicants should send a cover letter describing research experience and interests, a CV, and contacts for references to Steven E. Mansoor (mansoors@ohsu.edu).

 

The Mansoor Lab studies the molecular structure and function of ion channels and receptors in the cardiovascular system to develop novel small molecules for the treatment of conditions such as hypertension, angina, and platelet aggregation. Typical techniques and experiments in the lab include, but are not limited to, molecular biology, tissue culture, electrophysiology experiments in both Xenopus oocytes and mammalian cells, and protein expression and purification preparations to get isolated receptor for structural studies, including both X-ray crystallography as well as single particle cryogenic electron microscopy. Applicants must have prior biochemistry and molecular biology experience and be comfortable with these types of experiments. Preference will be given to applicants with previous training in membrane protein biochemistry, X-ray crystallography and/or cryogenic electron microscopy.

• Primary Research (including planning, granting, execution, analysis, publication) 

• Maintain laboratory compliance documentation for human, animal, biological and radiological work.

• Be familiar with lab safety infrastructure and ensure compliance with all safety regulations.

• Interact with biosafety, chemical safety, and safety officers on behalf of the Principal Investigator. 

• Generate data and research analysis for investigator's use in preparation of technical reports and publications.

• Assist the PI with manuscript preparation and grant applications.

• Present, or assist in the presentation of, research projects at retreats, seminars, conferences and other OHSU or public venues. 

• Providing training to users on lab practices and protocols, including sample preparation and instrumentation use. 

• Maintain an accurate and detailed laboratory notebook of all experiments performed. Participate in lab meeting. 

• Training of lab personnel and supervision of Research Assistants, students and other lab members. 

• Perform routine lab operations, including but not limited to the purchase of laboratory supplies, monitoring supplies and maintaining all laboratory equipment. 

• Other responsibilities as assigned by the supervisor in furtherance of the lab’s research and the university’s missions and goals of teaching, research, patient care, outreach and public service. 

• Ph.D. in biological sciences. 

• Independent graduate-level research in biochemistry, molecular biology, structural biology, biophysics or cell biology.

• Demonstrated independence in preparing and delivering oral presentations and manuscripts.

• Experimental design and interpretation of results.
• Basic molecular biological methods of DNA manipulation and analysis.
• Gene analysis techniques.
• Basic protein analysis techniques such as western blots, immunoprecipitation and immunostaining skills, mammalian cell culture.
• Strong organizational and interpersonal skills.
• Strong scientific curiosity, problem-solving skills and research integrity.
• High attention to detail and accuracy.
• Demonstrated success working independently and as a member of a collaborative team.
• Ability to communicate effectively, in both written and oral formats.
• Working knowledge of office computer applications, such as Word, Excel and PowerPoint.

• PhD in Biochemistry or Biophysics/Physics.

• Experience with research in structural biology (X-ray crystallography or Cryo-EM).

• Experience with cell culture techniques.

• Experience using PCR.

• Programming using Unix.

• Knowledge of membrane protein biochemistry.

Position is located at the OHSU Marquam Hill campus in Portland, Oregon. The work schedule will be set by the supervising faculty, dictated by the needs of the research and planned experiments. Working evenings, weekends and extended hours may be required depending on the needs of the research. Work environment is in an open wet lab, in the presence of laboratory chemicals and automated equipment.

Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.