We seek a highly motivated and organized Research Associate to join our collaborative team of basic, translational, and clinical scientists. The successful candidate will play a pivotal role in developing and characterizing preclinical models of rare pediatric and young adult cancers. This role involves co-leading the generation of various primary tumor models, encompassing both ex vivo and in vivo approaches. The Research Associate will develop ex vivo 3D cultures, such as organoids and explants, alongside in vivo patient-derived xenografts (PDXs) in immunocompromised mice.  Responsibility will include handling, survival surgery, drug administration, and tumor monitoring.

 

To effectively interrogate these patient-derived tumor models, the Research Associate will conduct a range of bioassays, including RNA/DNA analysis, NGS, immunohistochemistry, immunocytochemistry, western blotting, fluorescent imaging/microscopy, and flow cytometry. This work may include testing and validating novel drug candidates and combinations, as well as performing dependency screens using siRNA or CRISPR/Cas9.

 

The successful candidate will contribute to laboratory organization and management, ensuring regulatory compliance, and training junior staff as needed. They will also have the opportunity to actively participate in manuscript writing, presentation of findings, and knowledge sharing within the lab. The ideal candidate will possess meticulous attention to detail, the ability to learn new data analysis methods, and proficiency in analytical and graphics software routinely used to make figures (e.g., Prism, Adobe Suite, Excel). Strong communication and collaboration skills are essential for successful interactions with diverse team members and external collaborators.

 

***This position will be hired on a short contract with the possibility to renew***

• Master's Degree in with major courses in Cancer Biology, molecular biology and biochemistry AND 3 years of relevant experience OR
• Bachelor's Degree in relevant field AND 5 years of relevant experience.
• Animal handling and aseptic mammalian cell culture experience.
• The successful candidate will work in a lab setting and must have good communication skills, excellent recordkeeping and computer skills; and possess the ability to work independently while functioning within a team environment.

• Western blotting, functional cell/organoid based assays.
• Data analysis software skills using Microsoft Excel, Graphpad Prism and/or R-studio.

Location of employment is in molecular biology research lab. Work involves possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids, presence of carcinogenic substances and human and animal tissues and fluids, including whole animals

 

 

 

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Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.