The Teresa Zimmers and Leonidas Koniaris laboratory uses human biospecimens, cell culture models, and mouse models to interrogate and understand the physiological response to injury or illness including liver injury, kidney injury, burn injury, and cancer. We seek novel targetable mechanisms to block adipose and muscle wasting in cachexia in order to promote function, quality of life, healing, and survival. The laboratory is highly collaborative, working closely with other labs and centers at OHSU and around the world. Funding is derived from OHSU, the Brenden Colson Center, the Knight Cancer Institute, NIH, and the Veterans Administration.

 

The Senior Research Associate will work jointly under PI’s Zimmers and Koniaris and will execute various murine injury models, in vitro studies, and analyses of human biospecimens. The position requires expertise in mouse modeling including surgery, common cell and molecular biology techniques, including cell and tissue processing, cell culture, tissue dissociation, DNA/RNA isolation, PCR, Western blotting, ELISAs, and gel electrophoresis. The candidate must possess exceptional organizational skills and a detail-oriented management style. An ability to work independently, as well as collaboratively, and to help train and supervise entry-level staff, students, and interns is required. The SRA will lead projects and lead or contribute to manuscripts and presentations, and like all members of the laboratory, will contribute to shared laboratory chores, record keeping, ordering, compliance, etc. The SRA, like all full-time lab members, will contribute to training of rotation students and summer students and will present at laboratory meetings and other research meetings. The SRA will have the opportunity to receive professional development and mentoring, including attendance at external training opportunities and national and international conferences.

• Managing junior lab members: on-boarding and introduction to essential lab functions
• Designing and executing experiments; identifying, testing, and implementing novel experimental and organizational procedures in the lab, collecting, analyzing, and quantifying data;
• Assist with IACUC/IRB renewals, submitting amendments as needed for ongoing research in the laboratory. Ensure laboratory compliance with EHS policies.
• Co-author manuscripts for peer reviewed publication. Support grant applications for funding of the research laboratory.
• Attending and presenting research at lab meetings, seminars and conferences.

• PhD in relevant field AND 1 year of relevant experience OR
• Master's Degree in relevant field AND 5 years of relevant experience OR
• Bachelor's Degree in relevant field AND 9 years of relevant experience
• Experience in an academic biomedical research laboratory using mouse models and advanced analyses including omics approaches.
• Demonstrated ability to lead a project with agency and independence.
• Demonstrated facility with mouse modeling, mouse genetics, colony management.
• Demonstrated ability in analysis of high dimensional data, e.g. transcriptomics, genomics, proteomics.
• Demonstrated competence in analysis of biological pathways using human and/or murine biospecimens (histology, ELISA, preparation of samples for advanced omics analysis) and complementary studies using in vitro systems including genetic manipulation of primary cells, tissues, and cell lines.
• Ability to design, execute, troubleshoot and interpret experiments.
• Ability to master OHSU specific administrative systems for laboratory functions including IACUC, IRB, IBC, ordering, compliance, etc.

• Ability to organize the laboratory records and inventory.

• Ability to work independently as well as collaboratively. Ability to work in a team environment.

Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.