The OHSU Knight Cancer Institute, known as one of the pioneers in personalized cancer medicine, is an international leader in research and cancer treatment. Driven by its mission to end cancer as we know it, the institute is building upon its expertise in targeted treatments to advance the early detection of cancer when the disease is most treatable.

 

Every Knight Cancer employee is expected to embody our guiding principles: 

• We act BOLDLY—Breakthroughs require pushing the boundaries of science, exploring new frontiers, and thinking differently
• We SUPPORT each other—Respect leads to trust, which leads to excellence
• We work as a CONNECTED team—We must leverage our collective brain power to conquer cancer because no one individual can do it alone

We have an opening for a Senior Research Associate (SRA) Neuro Oncology to interrogate the molecular and immunological underpinnings of brain cancers. This is an outstanding opportunity for a highly motivated and ambitious scientist to thrive and obtain first-author publications, and grants to allow him or her to become an independent Principal Investigator in the future.  This position will utilize cutting-edge multi-omic approaches—including single-cell sequencing, spatial transcriptomics, and proteomics. The role involves developing and managing animal models, organoids, and patient-derived xenografts (PDXs) of gliomas. In this position, you will work on one or more of the following projects: (i) Molecular mechanisms of resistance to targeted therapies in gliomas, (ii) T cell function in brain cancer, and (iii) Immune profiling of checkpoint-mediated neurotoxicity.

 

The appointment length will be up to 36-48 months with a potential for extension. Initial appointments and extensions are subject to performance and funding.

 

Key Responsibilities:

• Plans, directs, and conducts in vitro and in vivo experiments, providing timely data analysis and interpretations.
• Oversee laboratory vivarium colonies and perform genotyping/phenotyping of knockout mouse strains for in vivo studies.
• Performs flow cytometry and scRNA seq for immune cell analysis from patient, clinical trial and in vivo samples.
• Collaborate with local and national partners to manage sharing of clinical samples (tumor, blood, and CSF) and databases.
• Train and supervise junior scientists and trainees, fostering their technical skills, and lead the research directions of the laboratory.
• Generate preliminary data and figures for lab meetings and grant proposals.
• Contribute to manuscript drafts for research publications.

Education & experience:

• PhD in relevant field AND 1 year of relevant experience OR
• Master's Degree in a relevant field AND 5 years of relevant experience OR
• Bachelor's Degree in a relevant field AND 9 years of relevant experience

Knowledge, skills, and abilities:

• Strong background in cancer biology and immunology is essential.
• Proven track record of impactful research, evidenced by first-author publications in peer-reviewed journals.
• Proficiency in in vivo and in vitro techniques and flow cytometry.
• Experience with RNAseq, scRNAseq, ATACseq, and analysis.
• Ability to prioritize multiple tasks at one time
• Excellent communication, analytical and organizational skills:  both written and verbal
• Ability to work independently and as part of a team while being collaborative in resolving problems
• Intermediate skills with Microsoft Office (Excel, Outlook, Access, Word, and PowerPoint) on Window OS. Ability to accurately type 60wpm
• Must have demonstrated excellent customer service skills both on the phone and in person
• Must possess energy and drive to coordinate multiple projects simultaneously
• Ability to use tact and diplomacy to maintain effective working relationships

• PhD in Biological Sciences (Immunology, Molecular and Cellular Biology, or Quantitative Biology) and at least five years of relevant experience.

Apply online. Please be sure to upload a Cover Letter and Resume/CV.

 

We offer a variety of benefits on top of joining a thriving organization:

• Medical, dental and vision coverage at no or low cost to employees
  • Covered 100% for full-time employees and 88% for dependents
• Several retirement plans to choose from with contributions from OHSU
• 25 days a year of paid time off
• 8 days of sick time off
• Commuter subsidies
• Tuition reimbursement
• Access to group life insurance, disability insurance and other supplemental benefits
• Annual Merit Increase
• Growth/Development Opportunities
• Employee discounts to local and major businesses

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Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.