The lab of Stephen Back, M.D., Ph.D. at Oregon Health & Science University (OHSU) in Portland, Oregon, in close collaboration with the laboratories of Jacob Raber, Ph.D.at OHSU and of Cecily Bishop, Ph.D. at Oregon State University (OSU) in Corvallis, Oregon, is seeking a candidate for a Postdoctoral Research Associate position to study the effects of fetal and neonatal intermittent cerebral hypoxemia on brain development. The lab currently has NIH funding for studies to explore the sequelae of maternal sleep apnea on fetal and postnatal brain development. Despite the fact that maternal sleep apnea commonly occurs in roughly 20-40% of human pregnancies, the long-term impact on brain development and neurobehavior is unknown. Studies are currently underway in a fetal ovine model to understand the effects of maternal intermittent hypoxia using a multidisciplinary approach that utilizes high field ex vivo MRI, hippocampal electrophysiology and neuronal morphometric studies to define the impact of maternal intermittent hypoxia on fetal brain development. All of these approaches are well established in the lab (see for example: Sci Transl Med 5(168):168ps2, 2013; Journal of Neuroscience, 39(40):7853-7871, 2019). The position will involve complementary pioneering studies to be conducted both at OHSU and OSU to study the postnatal neurobehavioral effects of intermittent maternal hypoxia during pregnancy on the offspring as neonates and young adults.
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