The successful applicant will work in the laboratories of Dr. Ninian Blackburn (Oregon Health & Sciences University) and Dr. Kelly Chacon (Reed College), both located in Portland Oregon. The primary focus is on the mechanism of copper export in the CusBCAF exporter which contributes to virulence in gram negative pathogens. This position will utilize advanced kinetic and spectroscopic approaches such as stopped-flow fluorescence and rapid-freeze quench x-ray absorption/emission methodologies. This position will likely provide guidance and supervision to students and lab technicians as appropriate. Extended out-of-town travel will be required. This description is intended to represent the overarching focus of this position – the responsibilities listed are not all-inclusive and additional responsibilities will be assigned as needed.

• Protein isolation and characterization with emphasis on determining metal concentrations and electronic structural properties.
• Measurements using rapid kinetic methods including stopped-flow and rapid freeze quench techniques.
• Analysis of rapid kinetic data.
• Spectroscopic measurements on metalloprotein structure/function, with an emphasis on fluorescence and X-ray spectroscopic techniques
• Developing protocols for isolation of intermediates.
• Computer modeling with an emphasis on spectral simulation.
• General biochemical laboratory techniques As needed.

• PhD in a relevant science discipline.

• General biochemical technique

• Specific techniques relevant to metalloproteins 

• Rapid Kinetics

• Spectroscopic techniques relevant to metalloproteins

• Computer modeling

• Some experience with membrane proteins

• Strong scientific curiosity and proven initiative to pursue solutions

• Strong writing skills

• Demonstrated success in prioritizing, organizing and handling multiple tasks and deadlines

• Demonstrated success working independently and as a member of a collaborative team

• Demonstrated skills in communicating complex scientific concepts to a variety of audiences, both verbally and in writing

• X-ray spectroscopy

• Fluorescence methods

• DFT and/or QMMM

• Primary location is the OHSU Marquam Hill campus in Portland, Oregon. However, expect local travel within Portland between the OHSU campus and the Reed College campus.
• Work schedule will be set by the supervising faculty within the general parameters of 40 hours per week. Evenings, weekends and extra hours may be required depending on the needs of the research.
• Approximately 3 times per year, will travel out of state to synchrotron facilities for 5 days per trip.
• Working in an open wet lab environment, in the presence of laboratory chemicals and automated equipment.

Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.