A postdoctoral position is available for a highly motivated candidate to contribute to our discovery program.  The successful candidate will perform studies in transgenic and knockout mice to dissect mechanisms underlying electrolyte homeostasis. Much of the work involves examining mouse kidneys using techniques such as the Isolation of Nuclei Tagged in specific Cell Types to enrich for single nucleus RNA-seq and performing transcriptomic analysis, using R and tools such as Seurat. We use mouse models treated with diuretics and other drugs for metabolic cage studies, Western blotting, immunofluorescence and kidney tissue clearing, Candidates with a doctoral degree and training and demonstrated competence in bioinformatics and snRNA-seq, are especially encouraged to apply.

• Participation in research studies, including maintenance and characterization of the renal physiology (renal injury, blood pressure and metabolic pathways) in transgenic and knockout mice and disease models. Microsurgical procedures, post-operative care, and metabolic cage studies will be performed.  Analysis of protein expression, transcriptomic analyses, tissue clearing and morphometrics, and metabolic cage studies are central.
• Perform experimental design and data interpretation.
• Preparation of manuscripts for publication, abstracts for presentation.  Full participation in Division and lab research activities.

• Doctorate degree in Medicine, Physiology, or Pharmacology
• Prior relevant experience in basic science laboratory. Experience in transcriptomics and RNA-Seq
• Coding in R
• Analysis using Seurat

 

• MD/PhD
• Experience with mouse models of kidney disease
• 2 or more published papers in peer-reviewed journals, especially if relevant to kidney

• General work schedule will be flexible, Monday-Friday (5 days/week). This position requires working with and handling animal models, research bench chemicals and reagents, and animal tissue/fluids.
• Ability to work at a computer for up to four hours at a time. Ability to carry and lift up to 50 pounds. Ability to stand for four continuous hours a day. Ability to move around the campus as needed for research studies and meetings.

Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.