This position requires a PhD in Developmental Biology, Gametogenesis and Preimplantation Embryo Development, Pluripotent Stem Cell Biology, Meiosis, or a closely related field. The successful candidate will conduct research focused on in vitro gametogenesis and the induction of haploidy in gametes derived from somatic cells.

 

The work will involve advanced gamete and embryo manipulation techniques combined with genetic, epigenetic, transcriptomic, genome editing, sequencing, and bioinformatics approaches in support of the mission and strategic initiatives of the OHSU Center for Embryonic Cell and Gene Therapy (CECGT).

The candidate will design and execute independent, hands-on experiments; maintain rigorous laboratory documentation; collect, organize, analyze, and interpret complex datasets; and prepare manuscripts for publication. Additional responsibilities include presenting findings at seminars and scientific conferences, developing experimental protocols, contributing to grant applications and progress reports, and preparing technical reports. The position also involves training and mentoring junior personnel. The role requires scientific independence, strong analytical skills, flexibility, and demonstrated expertise in developmental and stem cell biology.

 

Technical Research Responsibilities

• Independently perform somatic cell nuclear transfer (SCNT) and related gamete and embryo manipulation techniques to generate haploid mammalian gametes from somatic cells.
• Responsibilities include oocyte collection and enucleation; execution of SCNT and other advanced embryo micromanipulation procedures; embryo culture and assessment; isolation and characterization of blastomeres, embryonic stem (ES) cells, and induced pluripotent stem (iPS) cells; and generation of chimeric and transgenic animal models.
• Additional duties include routine maintenance of embryo and stem cell cultures; meticulous documentation and record-keeping; molecular characterization using sequencing technologies and bioinformatics analyses; and performance of histological, immunocytochemical, and other cellular and molecular assays.

Data Collection, Analysis, and Record Keeping

• Collect, analyze, and interpret scientific data relevant to ongoing research projects.
• Maintain comprehensive, accurate, and well-organized experimental records in accordance with institutional and regulatory standards.
• Ensure that all research data, protocols, and related documentation are systematically archived and readily accessible for current reference and long-term documentation.

Report Preparation and Literature Research

• Prepare analytical, descriptive, and evaluative reports for publication in peer-reviewed journals and for inclusion in grant applications, progress reports, and presentations at national and international scientific meetings.
• Conduct comprehensive literature reviews and database analyses to inform experimental design, data interpretation, and strategic research planning.

Other Duties

• Provide hands-on training in experimental techniques and established protocols.
• Delegate responsibilities appropriately.
• Oversee the work of students, trainees, and support staff to ensure high standards of scientific rigor, productivity, and compliance.
• Present research findings to fellow investigators and collaborative scientists; attend professional meetings.
• Perform additional tasks as required or assigned, to fulfill the mission of the Center for Embryonic Cell and Gene Therapy.

• Ph.D. in Developmental Biology, Stem Cell Biology, or a closely related field.

• Demonstrated record of first-author publications in peer-reviewed journals in relevant subject areas.

• Strong background in mammalian gametogenesis, preimplantation embryo development, and pluripotent stem cell biology.
• Excellent written and verbal communication skills.
• Demonstrated ability to think strategically and execute research plans efficiently within defined timelines.
• Strong analytical skills, with the ability to critically analyze, integrate, and interpret complex datasets.
• Ability to work independently as well as collaboratively within small, interdisciplinary teams.
• Proven ability to interact professionally and productively with diverse staff and trainees.
• Strong organizational skills, attention to detail, and the ability to prioritize competing responsibilities while coordinating research activities effectively.

• Demonstrated hands-on expertise in experimental embryology and advanced micromanipulation techniques (e.g., oocyte enucleation, nuclear transfer, embryo biopsy).
• Experience in derivation and culture of embryonic stem cells (ESCs) and related pluripotent stem cell systems.
• Proficiency in next-generation sequencing technologies and bioinformatics analysis.

Normal work schedule is routinely Monday - Friday, from approximately 9:00am - 5:00pm; however, early morning, evening, and weekend work is required by scope of the position. 

 

Work is performed in both the laboratory setting with potential risk of exposure to potentially hazardous chemicals and dry ice and in areas where there is potential risk of exposure to zoonotic agents through injury, by direct contact with animals or their tissues and body fluids or by contact with equipment contaminated by animals or their tissues and body fluids.

We are Oregon's only public academic health center.

In addition to caring for patients, we lead groundbreaking research. We also train the next generation of health care professionals. As Portland's largest employer, we give you opportunities to learn and advance in a system of hospitals and clinics across Oregon and Southwest Washington.

All are welcome.

OHSU welcomes people of all ages, ethnicities, genders, national origins, religions and sexual orientations. We are striving to build an anti-racist, multicultural institution and encourage people with diverse backgrounds to apply.

To request reasonable accommodation, contact askhr@ohsu.edu