Oregon Health & Science University

Cryo-EM Microscopist 4

Job Locations US-OR-Portland
Requisition ID
Position Category
Position Type
Regular Full-Time
Job Type
Salary Range
$53,301-$106,368, commensurate with experience
HR Mission
Drug Testable

Function/Duties of Position

We are seeking talented, motivated and interactive individuals to work as part of  a multidisciplinary team at the Pacific Northwest Center for Cryo-EM (PNCC) a joint collaboration between Oregon Health and Science University (OHSU) and the Pacific Northwest National Laboratory (PNNL).  The PNCC is a national facility serving and training researchers in the entire US. The Center, includes three 300 KeV cryo Transmission EMs (TEM) and one 200 KeV cryoTEM. A fourth 300 KeV cryo Titan Krios will be online in February 2020. These cryoTEMs will be outfitted with Falcon III, post GIF K3 or standalone K3 and volta phase plate technologies.  This center will also have all standard equipment for sample preparation and optimization. 


The successful candidate will assist in the day-to-day running of the facility, general laboratory maintenance, providing end user training, and large-data set acquisition for single particle and tomography cryoEM projects. Candidates will be able to provide essential research-related services utilizing Cryo-EM expertise and development of new services provided by the PNCC. Candidates are required to have an exceptional command of knowledge in Cryo-EM with a preference for research experience in structural biology or tomography.


The candidate will be expected to help maintain a smooth and efficient working environment and assist with training and support of PNCC users and new staff members.  This includes troubleshooting sample preparations, and setting up long semi-automated data collection runs for PNCC projects. 


Required Qualifications

  • Doctoral degree in the biological sciences (Biochemistry or Biophysics) OR Master’s Degree in relevant field and 5 years of relevant work experience OR Bachelor degree with 9 years of relevant work experience.
  • Demonstrated substantial experience utilizing transmission cryo transmission electron microscopes; and developing cryo sample preparation, imaging and analysis methodologies.
  • Strong working knowledge of instrumentation and techniques used in structural biology.
  • Demonstrated ability to learn new and innovative procedures quickly.
  • Maintain a high level of professional expertise through familiarity with current scientific literature.
  • Very well organized, dependable and efficient multi-tasker with strong time management skills.
  • Excellent communication skills with strong ability to organize, document and analyze research data.
  • Demonstrated ability to work independently and as a team member to accomplish research goals.
  • Demonstrated knowledge of basic computer software for data generation and record keeping.
  • Ability to follow lab safety regulations and lab compliance protocols.
  • Assists in preparation of technical reports

Preferred Qualifications

  • 5+ years experience in cryo TEM.
  • Previous experince using FEI Titan Krios or Arctica microscope, phase plate and direct electron detectors.

Additional Details

Please upload a cover letter and CV/resume, along with 3 professional references who can speak to your experiences and abilities with your application.


Working conditions: This position is located at RLSB on OHSU’s south waterfront campus; work hours are 8am – 5pm with occasional evening and weekend work as needed. Additional safety training will be required to work with infectious bacteria or viruses/ working with in a BSL-2 environment.


Physical demands & equipment usage: Ability to work at a microscope or computer for up to 6 hours at a time, with breaks. Ability to use and maintain microscopy and sample vitrification equipment. The worker is required to have close visual acuity to perform an activity such as: preparing and analyzing data; viewing a computer terminal; extensive reading. Ability to perform repetitive manual manipulations (gripping, grasping, fingering, pinching, etc.) Ability to move about campus in a timely manner in support of the research and mission goals of the PNCC. Ability to communicate complex ideas to users and co-workers. Personal protective equipment must be worn as required. (Gloves, eyewear, lab coat, etc.).


All are welcome

Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.


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