Oregon Health & Science University

Research Associate

Job Locations US-OR-Portland
Requisition ID
2021-9664
Position Category
Research
Position Type
Regular Full-Time
Job Type
Research
Department
Proteomics Shared Resource
Salary Range
$41,812 - 88,334. Commensurate with experience.
FTE
1.00
HR Mission
Research
Drug Testable
Yes

Department Overview

The OHSU Proteomics Shared Resource (PSR) facility was established to make state-of-the-art mass spectrometry-based protein analysis analytical capabilities available to the biomedical research community at OHSU. The PSR provides services to both internal and external clients outside OHSU, including supporting ophthalmological and cancer research by members of the Casey Eye and Knight Cancer Institutes. The PSR Research Associate (RA) will prepare samples for analysis, develop new methods of sample preparation, analyze samples using mass spectrometry, analyze data, provide result summaries to clients, and fully document all experimental work and procedures. They will also prepare standard operating procedures (SOPs); perform maintenance on mass spectrometry instrumentation, train clients on instrument operation and sample preparation, and assist in preparation of methods sections for manuscripts and grants. They will be expected to manage multiple projects within timelines assigned by the director and maintain high scientific and ethical standards. Working collaboratively with team members, the RA will promote a culture of transparency and traceability across all aspects of laboratory operations.

 

Function/Duties of Position

  • Prepare samples for proteomics analysis by LC/MS using standard operating procedures.
  • Develop and test new methodologies of sample preparation.
  • Document experimental work, analyze data, and present results.
  • Prepare and maintain standard operating procedures (SOPs).
  • Operate mass spectrometry instrumentation and perform troubleshooting and maintenance as needed.
  • Assist in the preparation of manuscripts and grant applications.
  • Other duties as assigned to support the PSR.

Required Qualifications

  • Bachelors degree with major courses in field of research
  • At least 5 years of postgraduate academic or industry experience.
  • Prior experience in operation of LC/MS systems.
  • Prior experience in either purification or analysis of proteins.
  • Knowledge and experience with protein sample preparation methodologies and proteomic workflows
  • Demonstrated ability to plan and execute research experiments
  • Ability to manage multiple projects within timelines according to high scientific and ethical standards
  • Proven collaboration and interpersonal skills to develop and maintain effective working relationships with team members, other OHSU employees, internal and external clients
  • Excellent verbal and written communication skills
  • Fast learner, flexible, with ability to make sound decisions and creatively problem solve
  • Receives occasional supervision
  • Exercise judgement in taking independent action, and seeks advice as necessary
  • Assist in planning experimental design
  • Assume responsibility for specific component of a research project
  • Responsibility for training clients in sample preparation and supervising students and volunteers
  • A mindful team member, able to promote a culture of transparency and traceability across all aspects of laboratory operations
  • Proficiency with MS Office Suite and databases

Preferred Qualifications

  • MS or PhD in Analytical Chemistry or closely aligned field
  • Extensive knowledge and application of proteomic sample preparation methodologies as applied to protein mass spectrometry workflows, implementing quantitative mass spectrometry-based strategies, including label-free analyses (DIA, PRM/SRM) and labeled (TMT) methods
  • Experience and knowledge in the operation and maintenance of different types of mass spectrometers, especially high-resolution mass spectrometers (Orbitraps or q-TOF)
  • Experience with MS software analysis pipelines

Additional Details

Working conditions: Typical weekly work week schedule; may sometimes require work on weekends or after 5 pm.

 

Physical demands & equipment usage:

Must be able to stand for up to four continuous hours per day. Must be able to communicate orally and in writing the results of scientific experiments; must be able to use a standard computer and screen up to 6 hours per day.

 

All are welcome

Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.

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