GENERAL LAB SUPPORT: - Assist in supporting the daily function of the lab, including the purchase of laboratory supplies, monitoring supplies and maintaining all laboratory equipment, under the supervision of the PI. - Provide Core Services including sample prep, imaging, data analysis and data distribution.  - Prioritize and identify daily work activities to achieve objectives of the lab. - Maintain detailed records and standardized protocols for training, and of experimental procedures, data collection and analysis methods. - Use computer software to input, manage and distribute data for future analysis. - Maintain an accurate and detailed laboratory notebook of all experiments performed. Participate in lab meeting. - Generate data and research analysis for investigator's use in preparation of technical reports and publications. Compliance & Safety Functions: - Be familiar with lab safety infrastructure and ensure compliance with all safety regulations. - Interact with biosafety, chemical safety, and safety officers on behalf of the Principal Investigator.

- Tissue culture of primary chick lens epithelial cells - SDS-PAGE and Western blot  analysis of samples generated from these lens cell cultures - Share of basic lab maintenance duties, including loading dishwasher and autoclaving tips and glassware - Maintain complete and accurate laboratory records of study procedures and results. - This position description may not include all duties of this position and additional duties may be added at the direction of Linda Musil, Ph.D.

The Department of Psychiatry at Oregon Health & Science University (OHSU), in partnership with other major Oregon health systems, has an outstanding opportunity for a psychiatrist interested in moonlighting. The Unity Center for Behavioral Health utilizes a non-coercive, highly community oriented treatment program, which prevents hospitalization when possible, and returns patients to community services as soon as feasible. This 100+ bed psychiatric hospital and 75-bed psychiatric emergency service in Portland, Oregon is a collaborative effort to address the mental health needs of the community.   The hospital is also a major training site for the department’s residency training program, medical students, and other health profession’s trainees. This is a unique opportunity for a creative, energetic psychiatrist to treat, teach and advance their academic interests.   Academic rank begins at the level of Adjunct Assistant Professor and may be higher depending on credentials. The position offers very competitive pay.   This posting will be used to fill multiple vacancies.

The appointee shall provide services as assigned by the supervisor in furtherance of the university’s missions and goals of teaching, research, patient care, outreach and public service.   The Department of Psychiatry at Oregon Health & Science University (OHSU) has an outstanding opportunity for a Psychiatric Mental Health Nurse Practitioner licensed in the State of Oregon to work at the State’s premier Adult Inpatient Psychiatric Service at Unity Center for Behavioral Health.  This position will be an employee of OHSU and credentialed at both OHSU and Legacy Health Systems, and will be embedded with an advanced team of dedicated, skilled OHSU and Legacy staff promoting outstanding behavioral health care.   OHSU’s Department of Psychiatry, in partnership with other major Oregon health systems, supports Unity Center for Behavioral Health by supplying staff to its 100+ bed psychiatric hospital and 75-bed psychiatric emergency service in Portland, Oregon.  We use a non-coercive, trauma-informed highly community-oriented treatment program and approach, which aims to prevent hospitalization when possible, and return patients to community services as soon as feasible.  The hospital is a major training site for the State’s behavioral health workforce, including trainees for two psychiatric residency training programs, and the state’s two medical schools.  In addition, Unity Center trains physician’s assistants, nurses, social workers, peer supports and other health profession’s trainees.   This is a unique opportunity for a creative, energetic Psychiatric Mental Health Nurse Practitioner to treat, teach and advance their academic interests.    The duties of this position include: - The Psychiatric Mental Health Nurse Practitioner at Unity Center for Behavioral Health provides behavioral health care to adult patients in the Adult Inpatient units.  - Participate in teaching of nurse practitioner students and occasionally medical students.   Academic rank begins at the level of Instructor and may be higher depending upon credentials. The position offers very competitive pay and benefits.

A successful candidate will have the opportunity to work under the mentorship of Dr. Joshua Saldivar to investigate key questions on nuclear dynamics that maintain the stability of genetic and epigenetic information. We are currently seeking a highly motivated fellow with expertise in molecular biology, cell biology, and/or epigenomics to work in the following NIH-funded areas: - Coordination of DNA replication and transcription– uncover mechanisms that spatially-separate replication and transcription zones, study S phase-specific transcription regulatory mechanisms that prevent transcription-replication conflicts, investigate dynamics of phase-separated transcription condensates across S phase. - DNA replication stress – induced epigenetic instability– determine the impact of replication stress on propagation of epigenetic information, uncover mechanisms that couple DNA replication to epigenetic stability, explore the role of balanced histone synthesis on maintenance of epigenetic information. - Novel ATR-CHK1 signal transduction pathways– investigate ATR-CHK1 regulation of transcription-related cyclin-dependent kinases, including CDK12, CDK13, CDK8, and CDK19; signaling and regulation of histone locus body processes; and phase-separation of mediator complex.

We are a large nonhuman primate (NHP) research program at the Vaccine and Gene Therapy Institute (VGTI) focused on - the collaborative development of cytomegalovirus (CMV)-based vaccine vectors for prevention and treatment of infectious and neoplastic diseases of global importance, including (in rough order of emphasis) HIV/AIDS, tuberculosis, malaria, Hepatitis B, influenza and prostate cancer, and - the development of novel approaches (both vaccine and nonvaccine) to cure established HIV/SIV infection.   To facilitate our goals the research group is comprised of faculty level Program Managers as well as an Administrative Support Group which includes a Laboratory Manager, Project Administrator (budget and compliance) and support staff for administrative duties, supply, procurement, reagent and inventory management, as well as a dedicated Flow Cytometry Group which supports the research focuses described below. Of note, our group interacts on a daily basis with the NHP Pathology Lab and the Infectious Disease Resource (IDR), and closely collaborates with other VGTI labs. Vaccine Development Program (Prevention) – The primary goal of this group is to continue to improve, understand and characterize recombinant CMV vectors for clinical translation. To accomplish this goal, the group is comprised of three primary Focus Groups including: - pre-clinical vaccine development and efficacy using the NHP model, - CMV immunobiology using molecular techniques, and - clinical translation.   Each Focus Group is led by a senior technician (Focus Supervisor). Focus Supervisors are supported by Focus Leads that assist in coordinating daily operations and management of technical staff (Research Assistants). HIV Latency Disruption and Immunotherapy Program (Cure) – The focus of this group has been to delineate the mechanisms of SIV pathogenesis in the rhesus macaque model and to understand the cellular and immunological factors that contribute to viral persistence during conditions of optimal immunologic or pharmacologic control.   Building on these discoveries, this group has expanded their efforts to include the development and testing of novel therapeutic strategies aimed at achieving eradicative cure or long-term remission from HIV/SIV replication after treatment interruption.  Therefore, the primary goal of this group is to continue to develop novel strategies aimed at eliminating latently-infected cells with the goal of facilitating remission from HIV/SIV replication after cART cessation. To accomplish this goal, his laboratory is comprised of two primary Focus Groups including: - HIV latency disruption and - HIV Immunotherapy.   Both groups are managed by a Focus Supervisor and supported by technical staff. Technical staff (Research Assistants) within all Focus groups will be expected to carry out the science associated with various projects and provide the technical support required to meet the program’s research objectives. Technical staff are expected to function independently or as part of a team to ensure all project goals are met. All staff are expected to carry out daily activities of the laboratory, including but not limited to: maintain detailed documentation of the experimental work (digital and physical records); ensure quality control of equipment, reagents and cellular material; work closely with lab members and with outside collaborators; perform and assist with experiments involving cell isolation, immunologic assays, microscopy, flow cytometry, and molecular biology; and maintain close communication with a supervisor regarding progress. The position will involve handling and processing human and non-human primate samples that may contain infectious agents.   Additional duties include, but are not limited to the following: - Under minimal supervision, sets up and performs various research procedures in support of research goals and grant commitments. - May lead one or more phases of a research project. - Performs work of moderate to complex difficulty. - May contribute to the planning, design, manuscript writing, grant or regulatory documentations, modification of studies and experiments. - With supervision, may interact with external research sponsors. - May oversee and assist with the training of junior staff. - Communicate with senior personnel regarding daily priorities (facilitate which assays take priority, if applicable). - Report equipment/supply needs or failures. - Monitor morning and evening checklists (ensuring the checklists are complete each day, updating them as new tasks inevitably arise). - Streamline daily workflow (and receive suggestions for improvements). - Complete all assigned trainings.  - Perform additional duties as assigned.

- Work on research experiments relating to the Cell Fusion/cyclic immuno-staining project as assigned by Drs. Melissa Wong and Summer Gibbs. These studies will include a variety of technical approaches including: cell culture, cell imaging, immunohistochemical, tissue scanning and evaluation, antibody validation, computational analyses. - Sample collection and processing. Interaction with clinical staff to facilitate identification and collection of samples. Possible consenting of patients onto IRB approved protocol. - Perform data analyses and entry and maintain data files on research projects utilizing various platforms (Microsoft Excel, Microsoft Access, RedCap, caTissue, ClinPortal, and others). - Immunohistochemical analyses, cell culture. - General Lab maintenance, including preparation of buffers and stocks, cleaning and organizing dishware, and racking and autoclaving tips/tubes. - Attendance at all laboratory research and division/department meetings.

This position is focused on research-based data analysis, including but not limited to, performing quantitative image-based analyses on FFPE multiplex stained tissue samples and generating initial data and reports. Position will contribute to the image analysis and computational side of multiplex imaging-based assays within clinical translational research studies, including high dimensional data analysis, computational methods and generating data for ML/AI applications, single cell analysis, clustering, dimension reduction, data normalization and multi-assay data integration. Responsibilities include:   - Process multiplexed images utilizing image analysis pipeline - Perform quality control of image data and image-derived resulting dataAssist in developing and implementing advanced computational algorithms to improve and scale the image analysis pipeline - Perform analysis and data visualizations to generate reports; discuss and communicate results - Participate in project collaborations with other teams, attend meetings and deliver requests Work is generally 40 hours per week during normal working hours, however, some evening and weekend work will be required.

- perform bench top cell biology (tissue culture, run gels, do westerns) - perform breeding and maintenance of mouse colonies - perform histological staining of tissues and in situ hybridization - participate in lab meetings, and contribute to publications

We are seeking a motivated Postdoctoral Fellow to conduct research in areas of tumor immunology and tumor microenvironment, identifying cells and their mediators, and epigenetic mediators of inflammation that critically regulate cancer development. Specific projects will be determined by the applicant’s skill set and articulated research interests. Experience in immunology, ex vivo tissue culture-based assays, and mouse models of cancer are a requisite.   The Postdoctoral Fellow will be the primary strategist in scientific aspects of the assigned project, and in that regard may participate in supervision of some activities of research assistants, frequently taking responsibility for expensive equipment and experiment design. It is expected that the Postdoctoral Fellow will write scientific papers, abstracts, and submit manuscripts for publication and seek out and apply for grants and additional funding to support this research.   Curriculum vitae (CV), one-page research description with relevant publications, and names/contact information for at least three professional references, should be uploaded with the application   Salary for this position aligns with the NIH Scale.

Grant writing – Applicant will submit a grant that fits the scope of their research and the stage of their career.   Manuscript writing – Applicant will submit a publication summarizing their research.   Applicant will manage and execute all experiments associated with their research project. The research project available consists of evaluating gene editing approaches in human stem cells and human retinal organoids. Experience working with iPSCs is preferred.   Applicant will perform necessary administrative paperwork to facilitate their research. This may include ordering supplies, regulatory approvals, etc  

Teaching trainees, medical students and support staff in accordance with assignments by the Chair. Teaching is done through assigned lectures to be given during the course of the year and through teaching in the course of performing their own job by modeling best practices, mentoring trainees and guiding learning through delegating graduated and focused levels of responsibility. Appointee shall establish and maintain a program of scholarly activities directed toward improving understanding of the causes, detection and treatment of diseases. The appointee shall have a demonstrated competence in teaching. This position also contributes to the administration of the department as assigned by the Chair; specifically, by helping select residents and participating in administrative committees and councils of OHSU as approved by the Chair.   Providing an outstanding level of professional performance (e.g. quality of investigation for research faculty; quality of clinical care for clinical faculty; quality of administrative function in education office). Professional performance is to be delivered in a manner that is compliant with the OHSU Code of Conduct. Appointee shall treat all patients, research subjects, trainees and co-workers with dignity and respect.   Maintaining a program of scholarly research activity directed toward improved understanding of the causes, detection, and treatment of diseases. May develop and direct scholarly research activities focused toward improving the educational foundation within dermatology. May engage in public service through consultative activities with OHSU and non-University groups as approved by the Chair. May also participate in additional departmental or hospital administration as approved by the Chair. (Optional)   Appointee shall have a demonstrated competence in research, teaching, patient care, administration or combinations of these activities. The potential for academic accomplishment should be evident.

Assist pharmacist through performance of the following technical support activities:  - Computer order entry of inpatient and outpatient orders; - Filling unit dose medication orders; - Select ordered medications from inventory to fill new orders or to provide 24-hours medication for distribution to patient's room; - Answering telephone, filing, billing / crediting and medication profile maintenance; - Load and refill medications into automated dispensing cabinet stations; - Maintain manufacturing logs and documents to ensure compliance with regulatory agencies.   Prioritize labels from new orders to assure that product is delivered to label location at least one hour prior to label due time.   Organize and restock work areas during and prior to end of shift, and remove expired medication.    Round to nursing locations; deliver items and remove  excess and discontinued oral dosage and injectable dosage units from patients’ bins and refrigerators and return to pharmacy for action.   Perform Unit Dose functions including: - Tube medications from pharmacy to hospital and clinic areas; - Repackage medications for unit dose dispensing; maintain and replenish stock for emergency trays and kits; - Return medications to stock and perform credits; - Record refrigerator temperature daily; - Process narcotics for removal from Pharmacy inventory and order replacements as needed; - Maintain barcode medication integrity by ensuring medications are barcoded before leaving the pharmacy. System optimization, hardware maintenance, user support, reporting, file transmission and assistance in problem-solving pertaining to automation and technology.   Performs a detailed and thorough audit of controlled substances medications dispensed for a patient and reconciles against products documented as adminisered or returned to the pharmacy for wasting. Demonstrates the ability to strengthen accountability, identify suspected diversion, and responds to known or suspected diversion incidents to avoid serious patient care, legal, and compliance implications.

Clinical: The Clinical Director for this location, working with the Department, will assign the clinical schedule. This position will work primarily as a general Orthopaedic provider providing care also for patients with orthopedic trauma surgical care needs. This position will be expected to take call, as assigned, with other providers on nights, weekends, and holidays.

Clinical Activities - Practice that emanates from the School of Nursing is expected to support the teaching and research missions of the School. - In the practice environment, teaching occurs concurrently with clinical activities. Specific duties include: - Provide supplementary coverage of labor and delivery calls when the permanent faculty are ill, in retreat, traveling professionally, on vacation, or leave. - The primary expectation is the provision of clinical midwifery services to patients in the faculty practice during both day and night shifts. Scholarly Activities: - Development of a program of research is an expectation of this position. Education Activities - Teaching graduate nursing students in the Nurse Midwifery programs. This includes teaching and leadership in program and curriculum development and advising and mentoring of students. Service Activities - These activities could include faculty meetings, committee membership, professional activities, and other responsibilities as assigned by the Program Director. Administrative Activities: - None. Other Activities - The appointee shall provide services as assigned by the supervisor in furtherance of the university’s missions and goals of teaching, research, patient care, outreach, and public service.

The CVICU team provides tertiary care to critically ill patients with cardiovascular disease while the NSICU team treats critically ill patients with neurological injuries. Care in both ICUs follows evidence-based guidelines and clinical pathways developed by the multidisciplinary team. This posistion is a dual appointment with .50 FTE occuring in the CVICU and .50 FTE occuring in the NSICU.The APP faculty is expected to work a fair share of weekday, night and weekend shifts. If desired, the APP faculty may choose a night shift-only assignment after an appropriate orientation period.   Clinical responsibilities: - Assessment and treatment of ICU patients under the direction of critical care trained physician faculty, including performance of basic ICU procedures. - Rounding on ICU patients with physician faculty, fellows and residents and developing and implementing clinical plans of care. - Consultation with specialty care providers when appropriate. - Communication with patients and families about medical conditions, treatment plans, and progress. - Working with hospital and unit staff to develop and implement discharge plans for patients in the ICU, and promote patient health through education and counseling. - Timely and accurate documentation in the electronic medical record. - Collaboration with other members of the multidisciplinary and interprofessional care team to ensure optimal patient care and continuously improve quality of care. - Adherence to best practice protocols and policies - Delivery of care compliant with the regulations and guidelines by the relevant regulatory bodies. - Treating all patients and co-workers with dignity and respect in alignment with the OHSU Code of Conduct. - Supporting a safe and welcoming environment where all can contribute and prosper. Education and Quality Improvement: - Orientation and education of trainees and nursing staff on the care standards and protocols in both ICUs. - Education of nursing staff, fellows, residents and medical students in formal and informal settings. - Participation in all relevant conferences and team meetings. - Collaboration with multidisciplinary and interprofessional care team members to establish or revise clinical pathways and patient education materials. Academic and professional development through attendance and/or participation at national/regional conferences is encouraged. The APP faculty may participate in a program of scholarly research activity directed toward improved understanding of the causes, detection, and treatment of diseases.

We are looking for a post-doctoral researcher with an interest in algorithm development of analytics for the large, diverse data sets generated by ORCATECH research projects.  This position is anticipated to last 1.5-3 years to allow adequate time for the researcher to integrate with the team and understand the available data.  Position may be hybrid or remote, with workspace available at OHSU’s main campus. Some travel may be required for conference presentations.   Current research projects a post-doctoral scholar could be involved with include the following: - Characterizing Older Mexican (American) Participation in Activity Digitally, Reliably, and Ecologically with the CART Platform (COMPADRE CART) is focused on monitoring real-world physical, cognitive, and social activity patterns in the homes of older Mexican Americans. - The Pacific Aging and Cancer Studies (PACS) is focused on learning about changes in patient functioning and quality of life in people undergoing cancer treatment by using unobtrusive, passive measurement technology. - Digital Evaluations and Technologies Enabling Clinical Translation for AD Study (DETECT-AD) is to improve early detection and monitoring of Alzheimer’s disease using a home-based system that continuously assesses a person’s activity and health in their home environment using simple devices (such as watches, electronic pill boxes, and bed mats), as well as blood tests, and brain scans. - Ecologically Valid, Ambient, Longitudinal, and Unbiased Assessment of Treatment Efficacy in Parkinson’s Disease (EVALUATE-PD) is an industry funded trial looking at the use of the ORCATECH home-based system, cognitive testing, and bloodwork to evaluate early-stage Parkinson’s patients and their care partners.

This position is full-time postdoctoral level (PhD in neuroscience or biophysics) in the von Gersdorff lab in the Vollum Institute. - Planning, executing, and analyzing experiments for independent research project(s) using electrophysiology, molecular, cellular, and live imaging and computational approaches in the retina and/or CNS. - Manuscript preparation for individual projects and assisting other lab members with manuscripts as needed. - Assisting the PI and other lab members with grant application (data acquisition, writing assistance, editing) as needed. Preparing fellowship applications. - Traveling to national and international meetings to present on findings. - Helping to mentor and train junior members of the laboratory.

- Provides research coordination and project management for multi-year research projects, and assists in planning design, procedures and executing research studies. - Responsible for training, mentoring and supervising research assistants, students, and junior staff. - Preparation of written reports, documents, correspondence, and peer-reviewed publications.

This position is primarily a research faculty position. Research responsibilities are to establish and maintain a grant-funded research program, with the expectation to develop an independently funded research laboratory.   This position will be assigned clinical duties, including weekend and evening call, commensurate with subspecialty expertise.   Educational responsibilities include participation in the instructional program for medical and graduate students, residents and fellows.   Service responsibilities include participation in committees and councils of OHSU; outreach and public service programs and professional societies.   The effort for this position at present is divided: 5% teaching; 15% clinical service; 80% research.