- Supports basic day-to-day functions of the lab, including assisting with ordering supplies.
- Carries out cell culture experiments with cell lines and primary human skin cells. Analyzes results using techniques listed in position summary.
- Helps to isolate DNA, RNA and cells from blood and biological fluid samples.
- Performs sequence analysis on blood and tissue-derived DNA from clinical study participants.
- Assists with maintenance of mouse colony and performance of mouse model experiments.
A Postdoctoral position in Cell, Cancer or Molecular Biology is available at the Knight Cancer Institute's Center for Experimental Therapeutics (CET). Interested candidates are expected to have recently obtained their PhD and have a strong track record of publications in Cell, Cancer or Molecular biology. Job duties include performing research to understand the role of newly identified drivers in the pathogenesis of cancer so as to identify novel therapeutic targets. The translational research projects within CET leverage multi-disciplinary approach in biology, chemistry, pharmacology, molecular modeling, in vitro and patient-derived models to probe complex biological processes and to pursue new therapeutic opportunities for various diseases. As a member of multi-disciplinary team, the postdoctoral candidate will receive training in various aspects of drug discovery & development for his/her career development.
- Perform hands-on experiments (in vitro and in vivo) and analyze/interpret data on assigned projects
- Critically evaluate relevant scientific advances and integrate this knowledge into research programs. Participate in project planning and execution
- Publish research in peer-reviewed journals and present work at scientific conferences. Effectively write and/or communicate research and regulatory materials. Attend and present at the project and group meetings and national conferences
- Provide medical and advanced practice management independently and/or in conjunction with attending physicians. Works in conjunction with attending physicians to provide continued clinical care in the inpatient and outpatient settings.
- Communicate with attending physicians, patients and families regarding patients’ conditions, treatment plans, and urgent medical needs.
- Assure appropriate setting of care (inpatient, critical care, acute care).
- Document subjective and objective findings, assessment and plan clearly and accurately in daily progress notes.
- Identify discharge needs early and communicate plan to patients, families, nurse case manager, and other healthcare team members.
- Work with nurses, social workers, nutrition services, pharmacy and others as needed to assure optimum patient care.
- Make appropriate referrals to specialty care service within OHSU and outside of OHSU.
- Consult with specialty care providers when appropriate.
- Maintain communication with external providers and other individuals and agencies (e.g. skilled nursing facilities) as appropriate.
- Perform clinical procedures as indicated (e.g. central venous access, chest drains, intubation).
- Adheres to best practice protocols and policies.
- Respond to and manage adverse infusion reactions and other emergencies, and review patient labs and physical conditions in order to override treatment parameters as appropriate.
- Ordering as needed (PRN) medications.
- Review urgent EKG’s, imaging, laboratory studies and other ancillary tests prior to start of treatment.
- Review investigational study EKG’s, imaging, labs and other ancillary tests prior to start of treatment.
- Provide consultation to OTU nurses.
- Consult with pharmacists on treatment changes and PRN medications.
Quality and Research:
- Work with clinic and hospital staff to optimize order sets, patient instructions, and other infrastructure that supports patient care.
- Identify and engage in opportunities to improve the quality and efficiency of care provided to trauma patients.
- Promote use of appropriate research findings in practice to exceed the standards of care.
- Work with the physician leadership, nurse managers, nursing staff and social workers to prevent and/or respond to patient complaints.
- Effectively manage resources.
- Participate as coinvestigator in clinical research studies.
- Accurately and efficiently record the History of Present Illness (HPI) and Review of Systems (ROS) into the Electronic Health Record
- Update the Past Medical History (PMH), Social History, Medications, Allergies;
- Specialty-specific metrics, visit Summaries, discharge summaries, while the clinician interacts with the patient.
- Accurately and efficiently record the details of the Physical Exam, Medical Decision-Making, Assessment and Plan, and pend any computerized Orders as directed by the clinician.
- Includes ICD Codes, prescriptions, diagnostics, referrals and medical equipment.
- Review patient charts, including outside records for information pertinent to the visit and include such information in the note per established workflows.
- Monitor the progress of labs, imaging, or other patient evaluation data, and record the results into the appropriate notes so the clinician can access the necessary information and make sound treatment decisions.
- Document and pend orders necessary for procedures being performed by the clinician using appropriate billing codes and medical terminology as required by the billing department.
- Place “Scribe Attestation” statement on every chart completed with aid of a scribe.
- Update “Provider Preferences” and specialty-specific training material regularly and as indicated.
- Attend all scribe meetings and proactively communicate with scribe trainer and manager as appropriate since work is done entirely at locations separate from where direct support and supervision can be provided.
Position will be hired at the Research Assistant 2 or Sr. Research Assistant level, while taking into consideration years of experience and internal equity (see Qualifications section for more information).
Qualities of a successful candidate:
- Highly-motivated with a basic background in molecular/cellular biology
- Creative and driven—able to analyze and apply computational tools to emerging genomic technologies to address basic and translational questions in our research area, including cancer metabolism, cancer therapeutics and biomarker discovery
- Committed to academic biomedical research
- Strong desire to learn and integrate biological and computational modeling techniques
Important findings will be further explored experimentally, both in our lab and through collaboration, with the ultimate goal of translating promising findings into clinical trials.
- Performs cell culture and mouse work, including drug treatments
- Performs basic molecular biology techniques including functional cell assays, PCR, Q-PCR, cellular imaging, DNA/RNA extraction, Western blots, etc.
- Data analysis (when possible using bioinformatics software)
Assists in the development of new assays in clinical samples
Responsible for independent implementation of experiments involving rodent models of psychiatric disorders that include surgical, viral, and behavioral manipulations. Duties include:
- Manage all aspects of an electrophysiology behavioral neuroscience laboratory including supervising all orders, preparation of regulatory protocol and research reports, training and supervising of students
- Independent implementation of experiments involving rodent models of psychiatric disorders that include surgical, viral, and behavioral manipulations
- Independent responsibility for research studies such as choice of antibody for a given paradigm
- Monitor expenditure related to federal grant research supply budget
An exciting opportunity is available for a Senior Research Assistant who has experience with cell culture methods. Additional experience with flow cytometry and data analysis is highly desirable. You will join an established project team working on an innovative bone marrow model.
- Cell culture experiments and maintenance of cells
- Assist with media changes and drug administration during experiment
- Prepare, run, and analyze flow cytometry samples
- Always exemplifies and promotes CEDAR culture.
- Independently participates in research execution of CEDAR program(s) and performs other general laboratory techniques
- Provides stability and continuity of knowledge as people and projects change
- Meets regularly with lab managers to identify potential synergies and reduce inefficiencies across projects
- Increased innovation and problem solving ability required
- Participate with some design of experiments or research studies and procedures to achieve project objectives
- Perform qualitative and quantitative research data analysis, programming, database development and management, research data visualization, and interpretation of a wide variety of research data, especially flow cytometry data.
- Prepares reports, charts, tables, and other visual aids to interpret and communicate data and results with a variety of programs, especially R, Excel.
- Conducts data/statistical studies in support of research proposals and protocols. Maintains and develops research gathering, retrieval and reporting systems.
Laboratory Organization and Compliance
Dr. Agarwal and her team for over past 15 years focusing on identifying novel signaling pathways that are requisite for leukemia initiation, clonal evolution, and drug resistance. This position will be a hybrid between wet lab and computational disciplines, with a dedicated mentorship in both areas. The new team member will help lead the project focused on understanding the mechanisms of leukemia initiation and drug resistance in a context dependent manner. The project will use variety of advanced molecular biology techniques, CRISPR methods along with single cell transcriptomic, epigenetic, and genomic profiling in premalignant and malignant models using murine and human cells in vitro and in vivo. The candidate should also be able to perform complex data analysis, along with downstream analyses using computational approaches. Applicants will need to possess strong technical and organizational skills as well as the ability to manage an independent project.
Laboratory and/or computational experience in the field of molecular/cellular biology, cancer biology or a related field is preferred. Experience with sequencing library preparation, epigenetics, flow cytometry, or murine models of disease would be especially beneficial. Achieving this position requires that the researcher have demonstrated a satisfactory track record of scholarly activity. We are looking for an enthusiastic individual who is capable and willing to make maximum use of excellent facilities and a productive environment.
Relevant publications for the position are below:
- Yang F, Long N, Anekpuritanang T, Bottomly D, Savage JC, Lee T, Solis-Ruiz J, Borate U, Wilmot B, Tognon C, Bock AM, Pollyea DA, Radhakrishnan S, Radhakrishnan S, Patel P, Collins RH, Tantravahi S, Deininger MW, Fan G, Druker B, Shinde U, Tyner JW, Press RD, McWeeney S, Agarwal A*. Identification and prioritization of myeloid malignancy germline variants in a large cohort of adult AML patients. Blood. 2022, 139(8): 1208-1221 PMC9211447, *Corresponding author. Prospective in ASH Clinical News, Selected for Podcast and Commentary in Blood 2022.
- Kurtz S, Eide CA, Kaempf A, Long N, Bottomly D, Nikolova O, Druker BJ, McWeeney SK, Tyner JW, Agarwal A.Associating Ex Vivo Drug Sensitivity with Differentiation Status Identifies Effective Drug Combinations for Acute Myeloid Leukemia. Blood Advances 2022, 6(10): 3062-3067.
- Hosseini MH, Kurtz SE, Abdelhamed S, Mahmood S, Davare, MA, Kaempf A, Elferich J, McDermott JE, Liu T, Payne SH, Shinde U, Rodland KD, Mori M, Druker BJ, Singer JK, Agarwal A. Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes. Leukemia. 2018, 32(11):2374-87. PMC6558520
- Carey A, Edwards D, Eide C A, Newell L, Traer E, Medeiros B, Pollyea DA, Deininger MW, Collins R, Tyner J W, Druker B J, Bagby G C, McWeeney S, Agarwal A*. Identification of interleukin-1 by functional screening as a key mediator of cellular expansion and disease progression in acute myeloid leukemia. Cell Reports. 2017, 18(13):3204-18. PMC5437102
- Agarwal A, Bolosky BJ, Wilson DB, Eide CA, Olson SB, Fan G, Druker BJ. Differentiation of leukemic blasts is not completely blocked in acute myeloid leukemia. Proc Natl Acad Sci U S A. 2019, 116(49):24593-24599. PMC690050. * Co-corresponding Author- Highlighted in “In This Issue PNAS”.
- Bottomly D, Long N, Schultz AR, Kurtz SE, Tognon CE, Johnson K, Abel M, Agarwal A……. et al; Integrative Analysis of Drug Response and Clinical Outcome in Acute Myeloid Leukemia. Cancer Cell 2022, in press (collaborative manuscript)
- This position will be assigned to the Anatomic Pathology Division, with responsibilities in Pediatric Pathology, which operates under a subspecialty sign out model. The responsibilities include the clinical service and teaching functions of the section Service and other assignments will be reviewed and modified by the department Chair, as needed.
- Your educational responsibilities include participation in the instructional program for medical and graduate students, residents and fellows of the Department as assigned by the Chair.
- Your service responsibilities include participation in committees and councils of OHSU; outreach and public service programs and professional societies with the knowledge and consent of the Chair.
- Your research responsibilities are to participate in clinical and basic research programs at OHSU as opportunities provide, and to work toward funding these studies through grants and contracts.
- The effort for this position at present is divided: 10% teaching; 80% clinical service; 10% research.
The Oregon Health and Science University (OHSU) Department of Diagnostic Radiology is seeking a faculty member for our Cardiothoracic Imaging Section. Appointment will be at the level of Assistant, Associate or full Professor, depending upon qualifications.
As the only academic medical center in the state of Oregon, OHSU provides a full spectrum of care to a large and diverse population, including the Knight Cancer and Knight Cardiovascular Institutes. Accordingly, the department has state of the art imaging equipment and sees patients with a wide mix of complexity and pathology. Academic activities within the section are centered on the promotion of excellence in the evidence-based application, performance, and interpretation of Cardiothoracic Imaging.
The campus offers excellent opportunities for multidisciplinary research, with a history of innovative and collaborative studies. OHSU is home to numerous specialized research centers and institutes, including one of the first Clinical and Translational Sciences Award-funded programs in the country (the Oregon Clinical and Translational Research Institute), the Advanced Imaging Research Center (dedicated to improving medical imaging), the Knight Cancer Institute, the Dotter interventional Institute, and the Knight Cardiovascular Institute. The Knight Cancer Institute is the only NCI-designated Cancer Center in Oregon.
Clinical responsibilities will include interpretation of all aspects of thoracic (CT/MR and radiographs) and cardiac imaging (CT and MR); as well as thoracic biopsies/aspirations. Familiarity with imaging of acquired and congenital heart diseases and imaging of minimally invasive techniques in the adult population is expected. Familiarity with cardiac imaging in the pediatric patient population would be desirable. Participation in numerous excellent weekly interdisciplinary conferences is expected. Educational responsibilities will include teaching at all levels commensurate with a large academic center, including medical student, resident and fellow training.
Candidates currently undertaking fellowship training in Cardiothoracic Imaging are encouraged to apply.
Oregon Health and Science University (OHSU) Department of Diagnostic Radiology is seeking a well-trained, subspecialized radiologist to join our Body Imaging team dedicated to outstanding patient care, resident and fellow teaching, and academic excellence.
Body Imaging Clinical responsibilities will include CT of the chest, abdomen and pelvis (including advanced applications such as three-dimensional imaging, CT urography, virtual colonoscopy and CT enterography), MRI of the abdomen and pelvis (including liver, biliary, prostate, gynecologic and genitourinary applications), general body ultrasound (including abdominal, pelvic, early pregnancy, and neck studies) image-guided needle biopsies, GI and GU fluoroscopic examinations, and attendance at interdisciplinary tumor boards.
The appointee shall provide services as assigned by the supervisor in furtherance of the university’s missions and goals of teaching, research, patient care, outreach and public service.
The duties of this position include: The Department of Obstetrics and Gynecology at Oregon Health & Science University (OHSU) and the OHSU Center for Women’s Health is seeking a Reproductive Endocrinologist at the Assistant or Associate Professor level. Expertise in clinical care and teaching is required. Physicians with proven skills in IVF and related technologies preferred. OHSU is an academic center; physicians with research interests in any of these areas are encouraged to consider this exciting opportunity.
This position includes responsibilities for teaching students, residents, and fellows. The ideal candidate will have outstanding clinical expertise, along with a strong commitment to scholarly pursuits. Applicants should be committed to teamwork, and mentorship of faculty, trainees, and students.
- Assist pharmacist through performance of the following technical support activities:
- Computer order entry of inpatient and outpatient orders.
- Filling unit dose medication orders.
- Select ordered medications from inventory to fill new orders or to provide 24-hours medication for distribution to patient's room.
- Answering telephone, filing, billing / crediting and medication profile
- Load and refill medications into automated dispensing cabinet stations.
- Maintain manufacturing logs and document to ensure compliance with regulatory agencies.
- Prioritize labels from new orders to assure that product is delivered to label location at least one hour prior to label due time.
- Prepare, mix and compound sterile medications, including chemotherapy.
- Adherence to aseptic procedures when preparing, mixing and compounding
sterile hazardous and non-hazardous medications.
- Performs pharmaceutical calculations in verifying dosage for medications to be prepared.
- Cleans and maintains primary and secondary engineering controls (e.g., vertical and laminar flow hoods) and equipment used to compound sterile hazardous and non-hazardous medications (e.g. repeater pump, work surfaces), discarding all non-preserved and/or non-labeled solutions in order to keep work area clean and orderly.
- Perform Unit Dose functions including:
- Tube medications from pharmacy to hospital and clinic areas.
- Repackage medications for unit dose dispensing.
- Return medications to stock and perform credits.
- Record refrigerator temperature daily.
- Process narcotics for removal from Pharmacy inventory and order replacements as needed.
- Maintain barcode medication integrity by ensuring medications are barcoded before leaving the pharmacy.
- Round to nursing locations; deliver items and remove excess and discontinued oral dosage and injectable dosage units from patients’ bins and refrigerators and return to pharmacy for action.
- Organize and restock work areas during and prior to end of shift, and remove expired medication.
- Perform other technician duties as assigned based on operational needs.
Design, develop, document, and administer research administration systems.
- Adhere and support the Software Development Lifecycle, which includes: planning, process analysis, technical design, development, customization, configuration, testing, training, implementation, and support.
- Analyze applications and systems to identify opportunities for simplification and/or enhancement.
- Prepare technical documentation based on deliverables.
- Adhere to ITG technical standards and processes
- Design and build system interfaces, customizations, inputs/user interfaces, workflow, and output files/graphs/reports.
- Evaluate system upgrades and new releases.
Support Business Processes:
- Review and analyze assigned department’s business processes and how each application supports these processes to help drive recommendations for system improvements or support.
- Provide ongoing technical support to existing research systems, and assure they are functioning correctly. Work with user project managers and business analysts to help troubleshoot problems.
- Conduct preliminary functional and performance tests. Document preliminary testing results and communicate these results.
- Assist in coordinating the efficient sharing of information between research systems.
- Assist in the development of systems to support research.
This position is currently 100% telework/remote and may include remote work long-term. Candidate must be able to work from home full-time initially.
- Conducts field analysis of deployed ITG core services including all manner of network infrastructure, proper operation of related services, security systems, virtualized environments, wireless, and wired Networks
- Monitors performance and proactively looks for system degradation or problem trends; provides feedback, problem assessment, and resolves the issues or proposes solutions to customers, and ITG support teams
- Provides analysis and testing of new hardware and software for integrity and usability
- Develops and/or participates in testing to assess the effectiveness and utility of temporary and permanent solutions for problems discovered in the field
- Analyzes special project technology requirements and recommends optimal hardware/software solutions
- Provides recommendations and assistance to other ITG staff in assessing and improving the tools, processes and procedures currently in use or proposed for future use.
- Develops and maintains expertise with current technologies and examine details of proposed future technologies to ensure effective and efficient deployment in research, and classroom environments.
- Participates in testing to assess the effectiveness and utility of proposed changes in tools, processes and procedures.
- Works with managers, technicians and customers to identify areas of concern and work to create efficient processes and procedures to ensure timely completion of projects, quality of support and resolution of problems; works collaboratively with other technical staff and management to identify trends and communicate issues that impact ITG personnel (root cause analysis).
- Assists ITG in developing a technology roadmap for the future.
Network Systems Administration
- Manage full lifecycle of network infrastructure equipment and services which includes planning, inventory management, configuration, communications, deployment, and ongoing support.
- Monitor network infrastructure, proactively addressing potential issues before they become service impacting, and reducing the impact when customers are affected.
- Mentor Field Technology Analysts and other ITG personnel when network related troubleshooting and service delivery is involved with their workflow.
- Use standard templates and models to deploy and configure ITG services. This includes all phases of operational work as well as all aspects of project work except service design which would require the input from a System Analyst Engineer.
- Utilizes the ITG Solution Development Life Cycle (SDLC) process to implement and support all assigned projects.
- Coordinates with OHSU facilities, space planning, outside vendors and other ITG work units to provide project planning, scheduling and resource management for internal and external IT field projects
- Participates in project kick-off, implementation, and support and milestone meetings for those projects that require ITG resources for implementation and support; reports issues and concerns to manager as appropriate.
- Acts as the advocate for both ITG and the user community to present and/or assess project-related technical solutions and tools for implementation of new solutions.
- Assesses daily priorities and coordinates projects, problem tickets and other work with desktop support staff; monitor and report progress to management.
- Communicates issues arising from the need to incorporate (or not) modifications to desktop “builds” relating to updates in OS, NOS, hardware and/or drivers, based on experience and feedback from the field
- Staffing the Columbia Memorial Hospital Emergency Department as assigned by the Chair;
- participation in education of medical and paramedic students, house staff and nurses;
- participating in Emergency Department quality assurance activities
Provide supervisory oversight for 17-20 Animal Technician 1 & 2 positions and indirect supervision of approximately 1-4 Animal Technician 3 (leads) to assure optimal animal care and research program support for the OHSU Central and Waterfront (CWC) research community. Programs supported by DCM utilize a large variety of laboratory research animals, including but not limited to, fish, amphibians, birds and a wide range of rodent and non-rodent mammalian species. This position oversees husbandry personnel and their research support activities in quarantine, isolation, conventional, ABSL-2 and barrier-maintained animal programs in 11 facilities located across the CWC campus. The supervisor provides support to departmental and research staff by interpreting DCM policies and guidelines, participating in the development and revision of standard operating procedures (SOP), assigning and documenting technical training for employees, reviewing departmental operations, and writing manpower summaries and workgroup status reports for senior department managerial and veterinary staff. This supervisor will be responsible for the assignment of the daily workload assigned to husbandry technicians. The supervisor will assist the DCM Husbandry Manager with hiring, performance appraisals, and general management of personnel issues.
The LPN works to facilitate patient flow through the Dermatology Department and ensure an accurate and complete medical record for each patient. The LPN assists the medical provider by accompanying them during the medical history-taking and exam, recording details of both into the medical record, and coordinating departmental resources regarding tests, orders, radiology and results.
Under the direction and supervision of a Licensed Medical Professional or M.D., and in accordance with hospital policies and procedures, the LPN provides basic care as a member of the patient care team. Patient care activities are related to rooming, measuring, recording, and reporting patient information and performing simple treatments and procedures. The LPN recognizes and addresses age-appropriate needs when caring for patients. In addition, the LPN assists in maintaining the practice environment in a clean, orderly condition including cleaning and stocking rooms. Participates in ongoing professional development and competency assessment, and participates in ongoing quality assurance and quality improvement initiatives. Performs requirements for Staff Members as outlined in Compliance Roles and Responsibilities in OHSU Hospitals and Clinics.
This position provides care to a population with predictable dermatologic needs. As a member of the health care team, assists providers in caring for patients with acute and chronic dermatologic conditions and provides this care consistent with the OHSU and departmental policies and procedures.
This position performs in a manner, which maintains the confidentiality and privacy of each patient, promotes positive health habits through appearance and attitude. Supports and adheres to the Code of Conduct and Policies and Procedures of both OHSU hospital and clinics and the Department of Dermatology, models ethical and appropriate behavior, professional standards, compliance and personal integrity.
The appointee shall provide services as assigned by the division head in furtherance of the university’s missions and goals of teaching, research, patient care, outreach and public service. This position provides clinical care coverage at OHSU’s Doernbecher Neonatal Care Center with additional coverage at any of our OHSU affiliated or partner hospitals: PeaceHealth in Vancouver, Washington, OHSU Hillsboro and Adventist Health.
The duties of this position include:
- Leadership (not related to teaching or research):
There are multiple opportunities at regional neonatology facilities and at OHSU.
- Clinical Activities (not related to teaching or research):
This position provides clinical care at OHSU’s Doernbecher Neonatal Care Center. There will be some additional expectation of coverage at Vancouver, Washington and at our partner hospitals, Hillsboro Medical Center and Adventist Health. This position works with a multidisciplinary team to provide comprehensive care to neonatology patients.
- Administrative Activities:
As an OHSU faculty member this person would be required to participate in faculty meetings at the division and department level. All pediatric faculty members are expected to aid the division head and department chair in providing direction to the division and the department both on a day to day basis and as part of ongoing strategic planning and strategic planning.
- Scholarly Activities (research/writing, abstracts, grant supported work, presentations, etc.):
OHSU faculty members are expected to have some scholarly activity. This may be limited to educating learners as outlined below, but may also include research, and other grant supported work or academic papers and presentations in disciplines related to their field of expertise. Faculty members are often called upon to partner with other providers and members of the department or division research support staff in research activity. Faculty members are expected to participate in clinical research as needed, often with the help of trained research support staff and senior faculty principal investigators.
- Education (include types of teaching and types of student taught):
This position provides clinical education to fellows, residents, medical students, and nurse practitioner students participating in newborn care rotations. As part of the multidisciplinary team charged with educating learners in the neonatology environment, this person would be expected to provide feedback and evaluation, both formally and informally, of learners working in neonatology.
- Other Activities:
Faculty members may be called upon to serve on OHSU committees and in other activities as directed by the department chair or division head in furtherance of division, department, or OHSU goals and objectives.
We are a new lab at OHSU in the Department of Pediatrics. We use 2 model systems, zebrafish and planarians, to study adult stem cell biology, brain cancer stem cells, and neural regeneration. All of these topics are unified by the field of developmental biology and we use common molecular biology techniques and genetics to study these processes.
We are looking for a Research Associate who has experience with using model organisms to study molecular biological questions (preferably with zebrafish experience). In addition to the technical aspects of the job and a keen eye for details, this position will be integral to establishing the lab culture and work ethic going forward. Although daunting, the position allows for large amounts of flexibility in terms of time and project management, as well as building a lab from the ground up.
Please apply if any of this appeals to you and check out our previous research: https://lab.research.sickkids.ca/pearson/