The successful candidate will lead an experimental research program that primarily leverages model organisms (e.g., population reference mouse, fly or worm recombinant inbred panels) to explore the role of genetic variation in disease; candidates that combine this strategy with analysis of human cohorts would be particularly attractive. Research areas of interest include, but are not limited to: - Somatic (nuclear or mitochondrial) or germline genetic variation - Complex trait genetics of chronic disease (e.g., cardiometabolic disease) - Genetic determinants of intermediate phenotypes (e.g., chromatin structure, transcription, translation) - Next-generation sequencing/‘omics or high-throughput screening approaches to detecting novel roles of genetic variation in disease - Gene-environment interactions

The Division of Genetics at the Oregon National Primate Research Center (ONPRC), Oregon Health & Science University, is seeking to recruit investigators at the Assistant/Associate Professor level, with expertise in non-human primate (NHP) genetics, genome biology and/or genome-guided medicine. Research areas of interest include but are not limited to: the analysis of NHP genetic and genomic data to improve understanding of human disease; methods for genome or epigenome manipulation; using personal genomes to create patient-specific hypotheses about disease and subsequent genome-based therapy. The appointee shall provide services as assigned by the supervisor in furtherance of the university’s missions and goals of teaching, research, outreach and public service. The incumbent will complement ongoing research activities and expertise in the Division through programs that aim to develop genetic resources and tools that can be broadly shared with the global research community and strengthen bridges between NHP models and the human research world. The appointee will be expected to plan, develop, organize, and direct a fully funded and independent research program that incorporates the use of non-human primate models to elucidate fundamental insights into biology. Incumbents are expected to independently and effectively direct a research laboratory, seek opportunities for internal and external collaborative research studies, supervise research staff and trainees, publish regularly in peer-reviewed scientific journals, and present/participate in national or international meetings. Teaching obligations include lecturing as well as mentoring/supervising graduate and/or postgraduate trainees. Service obligations include participating on academic and service committees at the center, university, and national/international level.

The Research Associate will play a leading role in several ongoing research projects that primarily involve evaluation of retinal structure and function in nonhuman primate models of aging and eye disease and in response to experimental treatments.  This position requires a hardworking, dedicated individual who can work independently.  Primary roles of the incumbent will be to manage ongoing studies of cell and gene therapies for retinal disease in nonhuman primates, conduct many aspects of the studies, and prepare reports and publications. Duties will include retinal imaging, image analysis, behavioral and electrophysiological assessments of retinal function and vision, histological analysis including sectioning and immunohistochemistry, detailed analysis and organization of data, and ensuring proper animal care. Other duties will include blood sampling, anesthesia administration and monitoring, administration of medications, surgical support and other laboratory duties. Candidates who have experience with vision research are especially encouraged to apply. The following skills would be highly valued: retinal imaging including color fundus photography and ocular coherence tomography; electrophysiological evaluation of retinal function; experience with cell culture, especially embryonic and iPSCs and their differentiation.